肾上腺皮质腺瘤与嗜铬细胞瘤的电镜鉴别诊断  

Electron microscopic differential diagnosis between adrenocortical adenoma and pheochromocytoma

作　　者：郑晓刚[1] 陈旭东[1] 姜少军[1] 陆珍凤[1] 周晓军[1] 

机构地区：[1]南京军区南京总医院病理科,江苏南京210002

出　　处：《电子显微学报》2005年第5期497-500,共4页Journal of Chinese Electron Microscopy Society

摘　　要：通过对3例肾上腺皮质腺瘤和3例嗜铬细胞瘤的光镜和电镜观察,分析了这两种肿瘤的超微结构特点及电镜在其鉴别诊断中的作用。提出了肾上腺皮质腺瘤与嗜铬细胞瘤的超微结构鉴别要点:①肾上腺皮质腺瘤瘤细胞胞质内的线粒体管泡状嵴,胞质中见大量拥挤的管状和泡状滑面内质网;②嗜铬细胞瘤含肾上腺素和去甲肾上腺素两种不同类型的神经内分泌颗粒,粗面内质网发达。同时讨论了线粒体管泡状嵴发生的机理。The ultrastructural features of 3 cases of adrenocortical adenoma and 3 cases of pheochromocytoma were analyzed and correlated with clinical and pathological data. On electron microscopy, adrenal cortical adenomas express distinct cortical features, including tubulovesicular mitochondria, lipid vacuoles, and abundant, predominantly smooth endoplasmic reticulum. Membrane-bound dense core neurosecretory granules, mitochondria of the tubulolamellar type, and predominantly rough endoplasmic reticulum are characteristic features of pheochromocytoma on electron microscopy. The genesis of tubulovesicular mitochondria was discussed.

关 键 词：肾上腺皮质腺瘤 嗜铬细胞瘤 线粒体 超微结构 

分 类 号：R736.6[医药卫生—肿瘤] R361.3[医药卫生—临床医学]