奥氮平与氟哌啶醇治疗精神分裂症急性期的临床研究  

A controlled study of olanzapine and haloperidol in the treatment of the acute phrase of schizophrenia

作　　者：李朝[1] 刘登堂[1] 王慧芳[1] 王飚[1] 江开达[1] 诸索宇[2] 凌政[3] 

机构地区：[1]上海市精神卫生中心,200030 [2]复旦大学附属华山医院精神科 [3]复旦大学附属中山医院心理医学科

出　　处：《上海精神医学》2005年第5期275-277,共3页Shanghai Archives of Psychiatry

摘　　要：目的比较奥氮平与氟哌啶醇治疗精神分裂症急性期的疗效及安全性.方法奥氮平组30例,剂量范围10～20mg/d;氟哌啶醇组30例,剂量范围5～20mg/d,两组均以PANSS、CGI量表及TESS、RSESE量表评定观察2周.结果奥氮平组治疗精神分裂症急性期症状与氟哌啶醇组相比总体疗效相当.奥氮平组PANSS兴奋激越因子减分在第1周末(t=3.16,P＜0.05)及2周末(t=3.59,P＜0.05)优于氟哌啶醇组.奥氮平组的药物不良反应小.结论奥氮平治疗精神分裂症伴兴奋激越症状患者疗效较肯定,起效较快,副反应较小,安全性良好.Objective： To compare the efficacy and safety of olanzapine and haloperidol in the treatment of the acute phrase of schizophrenia. Methods： 30 cases were treated with olanzapine in a regimen of 10-20 mg/d ,and 30 cases were treated with haloperidol in a regimen of 5-20 mg/d, PANSS、CGI、TESS and RSESE were used to measure the efficacy and safety for 2 weeks. Results： It was found that the total efficacy of olanzapine in treating the acute phrase of schizophrenia was similar to haloperidol. The olanzapine group was superior to the haloperidol group in the first （t=3.16, P〈0.05） and second week （t=3.59, P〈0.05 ） of PANSS Excited Components subtraction. The olanzapinae group had significantly fewer side effects. Conclusion：Olanzapine shows a satisfactory effect and safety in treating the acute phrase of schizophrenia. It has rapid onset of response and less side effects than haloperidol.

关 键 词：奥氮平 氟哌啶醇 精神分裂症急性期 精神分裂症 急性期 治疗 临床研究 PANSS 总体疗效 药物不良反应 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]