ICAM-1、VCAM-1在脑缺血损伤炎症机制中的作用及调控  

Effect and modulation of ICAM-1 and VCAM-1 in the inflammatory mechanisms following cerebral ischemia

作　　者：张丽慧[1] 魏尔清[2] 

机构地区：[1]杭州师范学院医学院药理学教研室,浙江杭州310018 [2]浙江大学医学院药理学教研室,浙江杭州310031

出　　处：《中国药理学通报》2005年第11期1281-1285,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30271498);浙江省教育厅科研计划项目(No20020984)

摘　　要：细胞间黏附分子-1(ICAM-1)和血管细胞黏附分子-1(VCAM-1)在脑缺血损伤炎症过程中起着重要作用。脑缺血后ICAM-1和VCAM-1表达增加;ICAM-1、VCAM-1介导循环中的白细胞与内皮细胞黏附,进而浸润到血管外脑实质,导致缺血后炎症;抑制ICAM-1、VCAM-1表达及作用可减轻脑缺血损伤。1ntercellular adhesion molecules 1 （ ICAM- 1 ） and vascular cell adhesion molecule 1 （VCAM-1） play important roles in the inflammatory process of cerebral ischemic injury. The expression of ICAM-1 and VCAM-1 increases following cerebral ischemia; ICAM-1 and VCAM-1 promote ischemic inflammation throughmediating leukocytes adhesion to the endothelial cells and eventually migration into brain tissue; the inhibition of the overexpression and effect of ICAM-1 and VCAM-1 can reduce cerebral ischemic injury.

关 键 词：脑缺血 细胞间黏附分子-1 血管细胞黏附分子-1 

分 类 号：R743.31[医药卫生—神经病学与精神病学]