结直肠癌临床病理参数预后意义的多因素Cox回归分析  

Prognostic Significance of Clinico-pathological Variables in Colorectal Carcinoma,Analyzed by Cox Model

作　　者：黄建[1] 吴金民[1] 杨工 张苏展[1] 余海[1] 郑树[1] 

机构地区：[1]浙江医科大学附属第二医院肿瘤科

出　　处：《中国肿瘤临床》1996年第3期156-162,共7页Chinese Journal of Clinical Oncology

摘　　要：回顾性分析了自１９８０～１９８９年来接受手术治疗的７４２例大肠腺癌病例。通过对临床病理指标的单因素和多因素Ｃｏｘ回归分析，研究影响大肠癌患者预后的独立性因素。研究结果表明：淋巴结受累（β＝０．４９８２，Ｐ＜０．０００１）及肠壁浸润深度（β＝０．１２６５，Ｐ＜０．０３１２）是影响大肠癌预后的独立性指标。由此提示：Ｄｕｋｅｓ′分期（β＝０．６３３４，Ｐ＜０．０００１）是一项独立的预后指标，亦是判断大肠癌患者临床结局的最重要和最准确的依据。This retrospective study of patients with a histologically proven adenocarcinoma is to evaluate the prognostic relevance of clinical and pathological variables in colorectal carcinoma by univariate and multivariate analyses of Cox regression.742 patients with primary colorectal cancer were operated upon in our department between 1980 and 1989 and followed up until April, 1992 or death.This study showed that only 2 distinguished prognostic factors were identified: (1) involvement of lymphnode (βcoefficient=0.4982,P<0.0001); (2)depth of invasion of intestinal wall (β=0.1265,P<0.0312).It was suggested that Dukes'staging (β=0.6334,P<0.0001) be the only parameter which presented an independent prognostic significance.The authors concluded that Dukes’staging was the most important,reliable and best available factor in predicting the clinical outcome of colorectal cancer.

关 键 词：结肠肿瘤 直肠肿瘤 COX模型 病理参数 预后 

分 类 号：R735.350.2[医药卫生—肿瘤] R735.370.2[医药卫生—临床医学]