层粘连蛋白受体单克隆抗体对人肺癌细胞生长状态的影响  

EFFECTS OF MONOCLONAL ANTIBODIES TO LAMININ RECEPTOR ON GROWTH OF HUMAN PULMONARY GIANT CELL CARCINOMA

作　　者：吴珊[1] 高绪兰[1] 王勇[1] 李玉林[1] 

机构地区：[1]白求恩医科大学基础部病理学教研室,白求恩医科大学一院心外科

出　　处：《中国免疫学杂志》1996年第2期82-84,共3页Chinese Journal of Immunology

基　　金：国家自然科学基金

摘　　要：观察了层粘连蛋白受体单克隆抗体（ＭｃＢ＿１）对高转移能力的人肺巨细胞癌系（ＰＧ瘤）体外培养细胞生长状态的影响。结果显示ＭｃＢ＿１能明显降低ＰＧ瘤细胞的生长速度。提示肿瘤细胞体外生长的调控与层粘连蛋白（ＬＮ）及层粘连蛋白受体（ＬＮ－Ｒ）的作用密切相关。The effects of laminin receptor monoclonal antibodies(McB1) on the cell growth of human pulmonary giant cell carcinoma(PG) were investigated in the experiment. The results showed that monoclonal antibodies were able to reduce PG cell growth. It suggested there were closely relationship between laminin, laminin receptor and growth of turnor cell in vitro.

关 键 词：单克隆抗体 细胞培养 层粘连蛋白受体 肺肿瘤 

分 类 号：R734.203[医药卫生—肿瘤]