抑癌基因P53突变产物表达与卵巢癌预后的关系  

RELATIONSHIP BETWEEN THE EXPRESSION OF P53 PROTEIN AND THE PROGNOSIS OF OVARIAN CARCINOMA

作　　者：姜彦多[1,2] 王永信[1,2] 关婷[1,2] 王继红[1,2] 王晓牧[1,2] 

机构地区：[1]解放军第202医院 [2]中国医科大学第三临床学院

出　　处：《解放军医学杂志》1996年第1期38-39,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：采用免疫组织化学方法观察６９例卵巢癌组织Ｐ５３蛋白的表达情况，阳性率为５９．４％，随着分化程度的降低，Ｐ５３蛋白的表达增强，高、低分化癌之间Ｐ５３蛋白的阳性率有显著差异（Ｐ＜０．０５）。Ⅲ～Ⅳ期癌Ｐ５３蛋白的阳性率明显高于Ⅰ～Ⅱ期癌（Ｐ＜０．０１），Ｐ５３蛋白阳性的病例累积生存率明显低于阴性的病例（Ｐ＜０．０１），表明Ｐ５３蛋白表达是卵巢癌进展或预后不良的标志。he expression of P53 protein was observed on 69 patients with ovarian carcinoma by immunohis tochemical methods. The positive rate of P53 protein was 59.4%。 The expression of P53 protein increased when the degree of differentiation decreased. Significant difference was found in positive rate of P53 protein between the welldifferentiated and poorly differentiated carcinomas (P<0.05). The positive rate of P53 protein in Ⅲ～Ⅳ stage carcinoma was significantly higher than that in Ⅰ～Ⅱ stage ones(P<0.01). The survival rate of P53 pro tein positive patients was much higher than that of P53 protein negative ones. These findings suggested that the ex pression of P53 protein was an index for exacerbation or poor prognosis of ovarian carcinoma。

关 键 词：卵巢肿瘤 抑癌基因 P53蛋白 预后 免疫组织化学 

分 类 号：R737.310.7[医药卫生—肿瘤]