75mGy　X─线全身照射对荷瘤小鼠的抗肿瘤转移作用  

ANTI-METASTASIS EFFECTS OF 75mGy X-IRRADIATION OF WHOLE BOOY ON TUMOR-BEARING MICE

作　　者：金敖兴[1] 汪思应[1] 魏道严[1] 黄帼[1] 

机构地区：[1]安徽医科大学核医学教研室,安徽医科大学肿瘤研究室

出　　处：《癌症》1996年第2期87-89,共3页Chinese Journal of Cancer

基　　金：国家自然科学基金

摘　　要：经７５ｍＧｙＸ－线全身照射后，荷瘤小鼠肺肿瘤转移结节明显减少；与低剂量环磷酰胺（Ｃｙ）合用后，也可使荷瘤小鼠的肺转移结节减少。对荷瘤鼠体内免疫功能检测结果提示，小鼠脾脏ＮＫ活性、ＬＡＫ活性及对ＩＬ－２的反应性显著增强；当与低剂量Ｃｙ合用时，上述抗肿瘤免疫功能也提高，可见，低剂量照射能通过有效地激活体内抗肿瘤免疫功能而具有显著的抗肿瘤效果，它为低剂量照射在临床肿瘤治疗的应用提供了理论根据。After low-dose X-irradiation of whole body alone the pulmonary metastases of tumor-bearing mice were reduced. The anti-metastatic effect was better when 75mGy X-irradiation was usedwith low-dose of cyclophosphamidel(CY). The cytotoxicity of muritie splenic NK cell,IL-2 inducedLAK cell and reactivity of IL-2 incrensed significantly.fter tumor-bearing mice were treated with 75mGyX-irradiation. The above antitumor immune fuctions were also augmented when 75mGy of X-irradiationand Cy Were sued. These rusults demonstrated the low-dese of x-irradiation had effective anti-metastas-tic effect through the activation of in vivo antitumor immnity. It provided reliable evidence for the possibit-ty of clinical application.

关 键 词：肺肿瘤 抗肿瘤转移 低剂量 放射疗法 

分 类 号：R734.205[医药卫生—肿瘤] R730.55[医药卫生—临床医学]