荷人鼻咽癌裸鼠血浆MDA和SOD活性变化  

CHANGES OF PLA8MIC MDA AND SOD ACTIVITY IN NUDE MICE EEARING HUMAN NASOPHARYNGEAL CARCINOMA

作　　者：杨惠玲[1] 郑芹[1] 

机构地区：[1]中山医科大学病理生理教研室

出　　处：《癌症》1996年第2期108-109,共2页Chinese Journal of Cancer

摘　　要：利用ＢＡＬＢ／Ｃ裸小鼠（ｎｕｄｅｍｉｃｅ，ＮＭ）复制鼻咽癌（ｎａｓｏｐｈａｒｙｎｇｅａｌｃａｒｃｉｎｏｍａ，ＮＰＣ）模型，检测不同病期荷人ＮＰＣＮＭ血浆丙二醛（ＭＤＡ）和超氧化物歧化酶（ＳＯＤ）活性，并与正常对照组比较。结果发现荷瘤鼠血浆ＭＤＡ在潜伏期（７．５１ｎｍｏｌ／ｍｌ）已明显升高，至早期（２０．６７ｎｍｏｌ／ｍｌ）达高峰，随后逐渐下降，但晚期（６．１９ｎｍｏｌ／ｍｌ）仍高于正常水平（４．５４ｎｍｏｌ／ｍｌ）；在中期或晚期荷瘤鼠血浆锰－ＳＯＤ（Ｍｎ－ＳＯＤ）（２７．７３，１９．９７ｎｕ／ｍｌ）与对照组（７０．２Ｉｎｕ／ｍｌ）比显著降低。结果提示荷瘤鼠血浆ＭＤＡ或ＳＯＤ活性与ＮＰＣ有关。BALB/c nude mice(NM)bearing human nasopharyngeal carcinoma(NPC)was reproduced byhypodermic implantation of human CNE-2 cells into right-side of axillary fossa. The alteration of plasmicmalondialdehyde(MDA) content and superoxide dismutase(SOD)activity were monitored in latent,early,middle and late phases(at 5, 10, 20 and 30 days followed inoculation of CNE-2 cells)of NM bearing humanNPC respectively in comparison with that of control group.Results indicated that in latent phase plasmicMDA content (7.51 nmol/ml)increased sharply and was at its peak in early phase(20. 67 nmol/ml).Thiswas followed by a steady decline in its content, but in late phase its content(6.19 nmol/ml)still increasedmore markedly than that of the control group (4. 54nmol/ml).while plasmic MnSOD activity in middle orlate phase(27. 73 or 19. 97 nu/ml)decreased sharply in comparison with the control group (70. 21 nu/ml).These results suggestel that there is a relationship between plasmic MDA content or SOD activity and NPC.

关 键 词：鼻咽肿瘤 丙二醛 超氧化物歧化酶 

分 类 号：R739.630.2[医药卫生—肿瘤]