老年期抑郁症和轻度Alzheimer病的认知功能研究  

Study on the cognitive function between senile depression and mild Alzheimer disease

作　　者：袁勇贵[1] 叶勤[1] 李乐加[2] 陈图农[3] 李海林[1] 吴瑞枝[1] 陆蓉[1] 陈晔[1] 李毅[1] 梅刚[1] 顾晓瑛[1] 

机构地区：[1]南京医科大学脑科医院精神科,江苏南京210029 [2]南京医科大学脑科医院物理诊断科,江苏南京210029 [3]南京医科大学脑科医院心理测验室,江苏南京210029

出　　处：《中国老年学杂志》2005年第11期1294-1296,共3页Chinese Journal of Gerontology

基　　金：中央保健委员会保健专项资金(项目编号:苏C057);江苏省科技厅社会发展资金(项目编号:BS2002001)资助

摘　　要：目的了解老年期抑郁症(SD)和轻度A lzheim er病(AD)的认知功能差异。方法使用汉密顿抑郁量表(HAMD)、简易智能状态检查(MMSE)和日常生活能力量表(ADL)、韦氏成人记忆量表(WAIS-RC)和中国临床记忆量表对60例SD患者、30例轻度AD患者和30例正常老年人进行评定。同时在治疗前对他们进行P300测量。结果SD和轻度AD患者的MMSE、WAIS-RC和记忆量表评分均显著低于正常对照组,而ADL总分均显著高于正常对照组,但轻度AD患者的前3个量表总分又均显著低于SD患者,而ADL总分又均显著高于SD患者(P<0.05或P<0.01)。SD和轻度AD患者的P300的N1、P2、N2、P3潜伏期均显著长于正常对照组,SD患者的P3波幅显著低于轻度AD患者;但轻度AD患者的P300的N1、N2、P3潜伏期均显著长于SD患者;并且轻度AD患者的P300的P2波幅显著高于正常对照组(P<0.05或P<0.01),而SD的P2波幅与正常对照组无显著性差异。结论SD和轻度AD患者均存在认知功能障碍,但轻度AD患者较SD患者重。Objective To explore the difference in cognitive function between senile depression （SD） and mild Alzheimer disease （AD）. Methods 60 patients with SD, 30 patients with mild AD and 30 normal senile controls were measured by Hamilton Depression Scale （ HAMD）, Mini-Mental State Examination （ MMSE）, activity of daily living （ ADL）, Wechsler adult intelligence scale, and Chinese clinical memory scale. P300 was detected before treatment. Results The scores in MMSE, Wechsler＇s and Chinese scale of SD group and AD group were significantly lower than those of controls, total scores in ADL of SD group and AD group were significantly higher than those of controls ; The total scores of the former three divided measuring tables in AD group all significantly lower than those of SD, the total score of ADL in AD group all were higher than those of SD group （ P 〈0.05 or P 〈0.01 ）. Latent period of N1, P2, N2 and P3 in P300 of SD group and AD group were significantly longer than those in controls, P3 amplitude of SD group was significantly lower than that of AD group; but latent period of N1 , N2 and P3 in P3o0 of AD group were significantly longer than those of SD group, P2 amplitude in P300 of AD group were significantly higher than those of controls （P 〈0.05 or P 〈0.01 ）, there were no significant difference in P2 amplitude between AD group and controls. Conclusions The patients with SD and mild AD have cognitive dysfunction.esoeciallv the oatients with mild AD.

关 键 词：抑郁症 老年 Alzheimer病:认知功能 

分 类 号：R749.4[医药卫生—神经病学与精神病学]