反应性抑郁症、抑郁性神经症患者听觉事件相关电位P300的改变(英文)  

Changes of auditory event-related potential P300 in patients with reactive depression and depressive neurosis

作　　者：瞿玮[1] 黄希庭[1] 吴宗耀[1] 侯岷[1] 

机构地区：[1]解放军第三军医大学西南医院神经内科临床心理咨询中心,重庆市400038

出　　处：《中国临床康复》2005年第40期132-134,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：背景:反应性抑郁症和抑郁性神经症为心因性情绪障碍,临床上均有记忆力减退、注意力不集中、反应迟钝、思维迟钝等认知功能损害的主诉,患者这种主观体验是否属实,对这类疾病认知功能损害客观的实验室的依据较少。目的:了解反应性抑郁症及抑郁性神经症患者听觉事件相关电位P300改变与认知功能损害的情况。设计:病例-对照实验。单位:解放军第三军医大学附属医院神经内科临床心理咨询中心。对象:选择1997-09/1998-03解放军第三军医大学西南医院职工为正常对照组40人,男21人,女19人;年龄20～50岁。同期从本院心理咨询门诊选择与正常对照组年龄相匹配的患者80例,其中反应性抑郁症(简称反应症组)40例,男29例,女11例;抑郁性神经症(简称神经症组)40例,男24例,女16例。随机追踪10例P300异常改变患者为随访组,其中反应性抑郁症4例,抑郁性神经症6例。方法:所有入组的首诊患者及正常被试者在本院脑电生理研究室均采用听觉事件相关电位P300经典方式进行测试,同时由经过心理测评培训过的专业人员对两组患者情绪状态用Zung症状自评量表进行评定。主要观察指标:①80例患者首诊和治疗4周、8周后听觉事件相关电位P300的检测结果及Zung症状自评量表评分,正常对照组听觉事件相关电位P300的检测结果。②10例P300异常改变者治疗前、治疗后P300结果及Zung症状自评量表评分。结果:参加实验的反应性抑郁症患者40例,抑郁性神经症患者40例,正常对照组40人,全部进入结果分析。①两组患者各波潜伏期均显著长于正常对照组(P<0.05～0.01)。两组患者听觉事件相关电位各波波幅较正常对照组低,N1熏P2熏N2三波波幅呈总体下降趋势,接近显著水平;而反应症组P3波幅明显低于正常对照组眼穴10.39±4.40雪,穴15.11±4.16雪μV熏P<0.001演。神经症组各波波幅则明显低于正常对照组。�BACKGROUND： Reactive depression and depressive neurosis are both psychogenic emotional disorders, clinically manifested by memory deterioration, impaired concentration, slow reaction, and bradyphrenia, among other cognitive function impairments. These subjective experiences of such patients still need to be backed up for their actual presence by objective laboratory evidences, which, however, have been searcely available to our current knowledge. OBJECTIVE： To investigate the changes of auditor）＂ event-related potential （AERP） P300 in patients with reactive depression and depressive neurosis, and their correlation with cognitive function impairments. DESIGN： Case-controlled experiment. SETTING： Clinical Center of Psychological Counseling, Department of Neurology, Third Military Medical University of Chinese PLA. PARTICIPANTS： Forty normal control subjects were recruited from the staff of Southwest Hospital, Third Military Medical University between September 1997 and March 1998, including 21 male and 19 female subjects aged 20-50 years. Eighty patients were selected from the agematched outpatients of the same hospital seeking psychological counseling, including 40 with reactive depression （consisting of 29 male and 11 female patients） and 40 with depressive neurosis （consisting of 24 male and 16 female patients）. From these patients 10 with abnormal P300 potential were randomly selected for followed-up study, including4 with reactive depression and 4 with depressive neurosis. METHODS： All the patients and normal controls were subjected to conventional examination of AERP P300 in the Laboratory of Cerebral Electrophysiology, and psychological evaluation was carried out by specialists with the assistance of Zung Self-Rating Depression Scale. MAIN OUTCOME MEASURES： ① Results of AERP P300 examination and scores of Zung Self-Rating Depression Scale in the 80 patients upon admission and 4 and 8 weeks after treatment, and results of AERP P300 examination in the control group. ② Results

关 键 词：适应障碍 抑郁障碍 事件相关电位 P300 

分 类 号：R749.42[医药卫生—神经病学与精神病学]