非小细胞肺癌患者血清中角细胞生长因子水平的研究  

Study of Serum KGF Content in the Patients with Non-small Cell Lung Cancer

作　　者：陈刚[1] 高晓来[1] 林蘯 周彩存[3] 

机构地区：[1]苏州市立医院（东区）急诊科／ICU,215001 [2]苏州市立医院（东区）呼吸科 [3]上海肺科医院肿瘤科／呼吸科

出　　处：《中华临床医学杂志》2005年第11期20-22,共3页Chinese Journal of Clinical Practical Medicine

摘　　要：目的 探讨血清中角细胞生长因子（KGF）含量对非小细胞肺癌（NSCLC）的影响。方法 用ELASA方法测定10例肺艮性疾患和46例非小细胞肺癌（NSCLC）患者血清中角细胞生长因子（KGF）含量。测定10例健康者血清中KGF含量。结果 10例健康者和10例肺良性疾病患者血清中都有微量的角细胞生长因子（KGF），而肺癌患者血清中KGF含量（平均430．58Pg／ml）明显高于正常健康者和肺良性疾病惠者（P〈0.05），其含量与病理类型、病理组织分级和临床分期、淋巴结转移情况无关。2年随访46例中死亡12例，其血清KGF含明显高于34例生存者（P〈0.05），20例血清HGF〉／400Pg／m1，其生存率明显〈400pg／ml者（P〈0．05）。结论 增高的血清KGF在肺癌中预示了一种更具有侵袭性的生物学行为。血清KGF、含量水平可作为早期肺癌患者的高危因素的指标。血清KGF含量400Pg／ml可望成为不良预后指标的参照值。Objective To study the relationship of serum KGF content and survival on NSCLC patients. Methods We measured serum KGF content in 10 normal healthy people and 10 lung benign disease patients,and 46 NSCLC patients using ELISA to determine the KGF content before operation .Results KGF content in lung cancer patients （430.58Pg/ml） is significantly higher than of healthy people and lung benign disease patients（P〈0.05）.The content is unrelated to pathological types,differentiation situation and lymph node metastasis,46 patients have underwent 2 year following-up.of which.12 patients died and their serum KGF contents significantly higher than that of 34 survivors（P〈0.05）.The overall survival of 46 patients whose serum KGF level higher than 400pg/ml are significantly higher than that of patients whose serum KGF level are lower than 400pg/ml（P〈0.05）.Conclusion Elevated serum KGF level predicts more aggressive biology in lung cancer. Serum KGF level can be used as a high-risk indicator in early stage lung cancer patients. 400pg/ml of serum KGF content can de expectably used as a refence value of poor prognostic indicator,

关 键 词：血清 肺肿瘤 角细胞生长因子 

分 类 号：R734[医药卫生—肿瘤]