烟酰水杨酸对Collagen、ADP、AA诱导的兔血小板聚集的影响  

Inhibitory effect of nicotinylsalicylic acid on rabbit platelet aggregation induced by ADP,AA and Collagen

作　　者：朱敏恒[1] 吴越[1] 陈虹[1] 田卉[1] 刘洪海[1] 

机构地区：[1]石河子大学药物研究中心,新疆石河子832002

出　　处：《中国药理学通报》2005年第10期1232-1234,共3页Chinese Pharmacological Bulletin

基　　金：国家重点科技项目(攻关)计划资助项目(No96-901-01-70)

摘　　要：目的观察烟酰水杨酸(NSA)对Collagen、ADP、AA诱导的兔血小板聚集的影响。方法用比浊法测定了NSA体外、体内对兔血小板聚集的影响。结果NSA能明显抑制体外、体内Collagen、ADP诱导的血小板聚集,体外最大抑制率分别为55.7%、61.3%,体内最大抑制率分别为42.2%、74.8%。NSA对AA诱导的兔血小板聚集没有影响。结论NSA具有抑制Collagen、ADP诱导的血小板聚集的作用。其抑制作用具有明显的量效关系。Aim To investigate the effect of nicotinyl salicylic acid （NSA） on rabbit platelet aggregation induced by Collagen, ADP and AA. Methods Platelet aggregation induced by collagen , adenosine diphosphate （ADP） or arachidonic acid （AA） was studied with turbidimetry in rabbtis blood, in vitro and vivo. Results NSA significantly inhibited the platelet aggregation induced by Collagen and ADP, in vitro and vivo. The inhibition by NSA was dose-dependent. NSA had no effect on the platelet aggregation induced by AA. Conclusion NSA can inhibit rabbit platelet aggregation induced by Collagen and ADP.

关 键 词：烟酰水杨酸 腺苷二磷酸 花生四烯酸 胶原 血小板聚集 

分 类 号：R-332[医药卫生] R331.143