非小细胞肺癌中的PCNA、P53r、asP^(21)的表达  

The expression of PCNA,P^(53),rasP^(21) in non small cell lung cancer

作　　者：林风武[1] 戚良晨[1] 程苏影 王庚学 牟树峰 

机构地区：[1]吉林大学中日联谊医院胸外科,吉林长春130033 [2]吉林省蛟河市医院循环内科 [3]吉林省公主岭市医院外科 [4]吉林省白城市医院外科

出　　处：《中国实验诊断学》2005年第5期706-707,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨PCNA、P53r、asP21与肺癌临床病理特征的关系及联合表达的意义。方法应用免疫组化S-P法检测了81例肺癌组织(鳞癌46例、腺癌35例)、20例正常肺组织中PCNA、P53r、asP21的表达情况。结果PCNA、P53、ras-P21在肺癌组织中分别表达67%、54%、56%,而在正常肺组织中的阳性表达率分别为5%、5%、0%。结论PCNA、P53、rasP21对肺癌发生、发展有密切关系,如果能排除肿瘤类型、分期、淋巴结转移等因素的相互干扰,其准确性可能会进一步提高。Objective To investigate relationship between PCNA, P^53, rasP^21 and characteristics of lung cancer. Methods The immunohistochemicl s-p method was used to detect the expression of PCNA, P^53, rasP^21 in 81specimens of lung cance PCNA, P^53, rasP^21 issues and 20 normal lung tissues. Results The expression of PCNA, P^53, rasP^21 is 67%, 54%, 56% in lung cancer and 5%, 5%, 0% in normal lung tissues respectively. Conclusion The overexpression ofPCNA, P^53, rasP^21 is related to tbe occurrence and development of lung cancer. The significance may be improved ff the intterference among cell type, staging and lyraphaden metastases can be removed.

关 键 词：肺癌 PCNA P^53 RASP^21 

分 类 号：R734.2[医药卫生—肿瘤]