乳腺肿瘤三维超声血管容积指数与病理微血管密度相关性研究  

Correlation Between Three-dimensional Ultrasound Vascularity Volume Index and Pathologic Microvessel Density of Breast Masses

作　　者：张超学[1] 张新书[1] 王玲[1] 郑慧[1] 姜凡[1] 段开诚[1] 闻祥红[2] 

机构地区：[1]安徽医科大学第一附属医院超声科,合肥市230022 [2]安徽医科大学第一附属医院超病理科,合肥市230022

出　　处：《中国超声医学杂志》2005年第11期818-821,共4页Chinese Journal of Ultrasound in Medicine

摘　　要：目的研究乳腺肿瘤三维超声血管容积指数(VI)与病理微血管密度(MVD)的相关性。方法应用Tomtec 3D Sono ScanPro1.2对42例乳腺肿瘤进行三维重建,计算肿瘤的三维血管容积指数,对手术后的标本进行抗CD34因子免疫组化染色,测定肿瘤微血管密度。结果乳腺肿瘤的三维超声成像图立体感明显,其三维血管容积指数与病理微血管密度呈线性正相关,相关系数为rVI=0.90,P<0.001。结论VI能够较准确地反映乳腺肿瘤血管生成,对于乳腺肿瘤的鉴别诊断、乳腺癌的预后有着重要的临床应用价值。Objective To determine the relationship between three-dimensional ultrasound vascularity volume index （VI） and pathologic microvessel density （MVD） of breast masses. Methods 42 patients with breast masses were examined by three-dimensional ultrasound （3D-US）, calculate the three dimensional VI of breast masses. MVD was calculated in surgical specimens after immunohistochemical staining using anti-factor CD34. Results 3D-US provided a clear stereoscopic view of breast masses. These studies showed a significant leinear correlation between VI and MVD （rvl ： 0.90, P~ 0. 001 ）. Conclusions It suggested that VI could be used to assess breast mass angiogenesis. VI has a potential ability for differentiating breast mass and for predicting beast tumor prognosis.

关 键 词：乳腺肿瘤 三维超声 血管容积指数 病理微血管密度 疾病预后 鉴别诊断 

分 类 号：R737.9[医药卫生—肿瘤] R730.41[医药卫生—临床医学]