直肠癌腔内超声血管定量与TNM分期及病理微血管密度相关性研究  

Transrectal Doppler Ultrasonographic Quantification Correlated with TNM Stage and Pathologic Microvessel Density

作　　者：赵玉珍[1] 于跃明[1] 叶卫华[1] 杨漪[1] 薛逊[1] 纪晓惠[1] 

机构地区：[1]河北医科大学第四医院超声科,石家庄市050011

出　　处：《中国超声医学杂志》2005年第11期852-854,共3页Chinese Journal of Ultrasound in Medicine

基　　金：河北省卫生厅科技攻关课题(No.03010)

摘　　要：目的探讨直肠癌彩色血流平均密度(MCVD)与TNM分期、微血管密度(MVD)的关系。方法术前应用经直肠彩色血管能量成像(TR-CPA)计测直肠癌MCVD,术后确定肿瘤TNM分期、计数MVD,比较不同TNM分期间MCVD、MVD的统计学意义及MCVD与MVD相关性。结果(1)63例直肠癌MCVD与MVD呈正相关(rs=0.853,P<0.01);(2)不同TNM分期MCVD、MVD比较有显著性差异(P<0.05);(3)随TNM分期增高,MCVD、MVD值增加。结论MCVD能在术前客观显示不同TNM分期直肠癌的血供特点及病理微血管分布,可作为术前选择有效治疗方案、评估预后的可靠指标。Objective To explore the relationship of the mean color vessels density （MCVD） with TNM stage and pathologic microvessel density （MVD） in rectal cancers. Methods MCVD were caculated preoperationly with transrectal color power angiography （TR-CPA） .After operation all cases were staged according to TNM standard. MVD was assessed immunohistochemically using anti-CD105 monoclonal antibody. The statistical significance of MCVD and MVD in different TNM stages were analyzed. Then the correlation between MCVD and MVD was analyzed statistically. Results （1） There were positive correlation between MCVD andMVD （rs=0. 853, P〈0.01） in 63 cases of rectal cancer. （2） There were significant difference of MCVD and MVD in all TNM stages （P〈0.05） . （3） The higher TNM stages were, the higher MCVD and MVD were. Conclusions MCVD can display features of the blood supply and distribution of pathologic microvessels in different TNM stages of rectal cancer objectively. MCVD is a credible index to choose available treatment and to evaluate prognosis before operation of rectal cancer.

关 键 词：直肠癌 腔内超声 血管定量 TNM分期 病理微血管密度 

分 类 号：R735.37[医药卫生—肿瘤] R730.41[医药卫生—临床医学]