血管生成素受体在口腔癌的表达及其意义  

Expression and significance of Tie-2 receptor in oral squamous cell carcinoma

作　　者：武云霞[1] 梁萍[1] 南欣荣[1] 焦艳军[1] 孙晓军[1] 

机构地区：[1]山西医科大学第一医院口腔科,太原030001

出　　处：《现代口腔医学杂志》2005年第6期618-620,共3页Journal of Modern Stomatology

基　　金：山西省归国留学人员科研基金资助项目(编号200373)

摘　　要：目的探讨血管生成素受体(Tie-2)在口腔癌的表达水平及其在口腔癌血管生成中的作用。方法采用免疫组化SABC法,检测34例口腔癌组织及16例正常口腔粘膜组织中Tie-2、CD34的表达。结果Tie-2、CD34在口腔癌微血管内皮细胞的表达明显高于正常口腔粘膜血管内皮细胞的表达(P<0.05)。但随口腔癌病理分级的升高,Tie-2、CD34虽呈现递增趋势,但组间比较无显著性差异(P>0.05)。结论在口腔癌中,血管生成增加,Tie-2可能参与口腔癌血管生成的调节。Objective To investigate the role of Tie- 2 receptor m oral squamous cell carcinoma. Methods Tie- 2 and CD34 protein expression in 34 oral squamous cell carcinoma （OSCC） and 16 oral normal mucosa were detected by SABC immunohistochernical technique. Results Tie - 2 and CD34 expressed at higher level in OSCC than in the control oral mucosa（ P 〈 0.05） ; but expression of Tie - 2 and CD34 was not significantly positive correlated with pathological grade in OSCC（ P 〉0.05）.Conclusion Angiogenesis is increased in OSCC, and Tie-2 may be involved in the OSCC angiogenesis regulation.

关 键 词：血管生成素受体 免疫组化 口腔癌 血管生成 

分 类 号：R739.8[医药卫生—肿瘤]