一起放射性伤害事故受照者1.5年后染色体畸变随访观察  

A Follow-up Study on Chromosomal Aberrations in the Victim of Radiation Injury Accident After1.5 Years

作　　者：陈英[1] 孙偶君[1] 骆亿生[1] 刘秀林[1] 

机构地区：[1]军事医学科学院放射医学研究所,北京100850

出　　处：《癌变．畸变．突变》2005年第6期386-388,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：背景与目的:对广州放射性伤害事故受照者进行远后效应随访,观察迁延照射的细胞遗传学损伤特点。材料与方法:常规染色体畸变与G_显带核型分析。结果:双着丝点畸变下降缓慢;染色体总畸变率26%,其中以易位等稳定性畸变为主,未发现克隆样核型改变。结论:迁延照射造成的细胞遗传学损伤较一次照射严重,且修复缓慢。BACKGROUND ＆ AIM： To follow the late effects of victim in a radiation injury accident and observe the cytogcnctic characteristics of continual irradiation. MATERIAL AND METHODS： Conventional chromosomal aberrations and G-banded kayrotype analysis were used. RESULTS： There was gradual decline in dicentrics. Stable aberrations such as translocations played dominant role, accounting for 26% of the total aberration frequency. Clonal aberrations were not observed. CONCLUTION： There were more severe cytogenetic damage and slower repair in continual exposure to radiation than in a single irradiation.

关 键 词：迁延照射 染色体畸变 易位 远后效应 

分 类 号：R818.03[医药卫生—放射医学]