MTA1在鼻咽癌中的表达及意义  

Expression of the MTA1 gene in nasopharyngeal carcinomas.

作　　者：莫立根[1] 王会河[2] 赵惠柳[1] 邝国乾[1] 黄光武[2] 

机构地区：[1]广西医科大学附属肿瘤医院头颈外科,广西南宁530021 [2]广西医科大学第一附属医院耳鼻喉科,广西南宁530021

出　　处：《现代肿瘤医学》2005年第6期733-735,共3页Journal of Modern Oncology

基　　金：广西自然科学基金资助项目(项目编号:桂科青0229030)

摘　　要：目的探讨MTA1在鼻咽癌中的表达及临床意义。方法应用逆转录-PCR(RT-PCR)技术,检测43例鼻咽癌组织和14例正常鼻咽部组织中MTA1 mRNA的表达。结果MTA1 mRNA在鼻咽癌组织的平均表达水平明显高于鼻咽部正常组织(P<0.05)。鼻咽癌组织中MTA1 mRNA高表达率与临床分期、T分期和N分期呈正相关关系。结论MTA1基因过度表达与鼻咽癌浸润和转移密切相关。MTA1 mRNA的过度表达可能是评价鼻咽癌的恶性程度、转移的重要指标。Objective To study the relationship between the expression of matastasis - associaed gene 1 （ MTA1） gene and nasopharyngeal carcinomas progression. Methods Using reverse transcription polymeras chain （RT-PCR） technique on 43 nasopharyngeal carcinoma tissue cases and 14 normal nasopharyngeal tissue cases to detect mRNA expression. Results Average expression of the MTA1 gene in nasopharyngeal carcinoma tissue was higher than in normal nasopharyngeal tissue（p = 0. 000）. The frequency of MTA1 overexpression between clinical staging, T staging and N staging was very significant （P 〈 0.05 ）. Conclusion The results suggest that the overexpression of the MTA1 gene correlates invasion and metastasis of nasopharyngeal carcinoma. A high expression of MTA1 mRNA may be a potential indicator for assessing the malignancy of nasopharyngeal carcinoma.

关 键 词：鼻咽肿瘤 肿瘤浸润转移 MTA1基因 MRNA表达 

分 类 号：R739.63[医药卫生—肿瘤]