含吡喃阿霉素方案治疗转移性乳腺癌  

Regimen containing pirarubicin(THP) in treatment of metastatic breast cancer.

作　　者：徐波 李恩孝[2] 尚金堂[2] 肖菊香[2] 李毅[2] 李蓉[2] 

机构地区：[1]西安昆仑医院,陕西西安710043 [2]西安交通大学第一医院肿瘤内科,陕西西安710061

出　　处：《现代肿瘤医学》2005年第6期775-776,共2页Journal of Modern Oncology

摘　　要：目的研究含吡喃阿霉素(THP)联合方案对转移性乳腺癌的临床疗效及安全性。方法采用5-Fu 500mg/m2,THP 50mg/m2,CTX 500mg/m2。每3周重复,至少2周期,治疗40例转移性乳腺癌。结果总有效率57.5%,其中CR 5例。初治者及复治者有效率分别为73.7%及42.9%。曾接受ADR治疗者有效率41.7%。皮肤软组织、淋巴结转移者有效率为88.2%,肺、肝内脏转移者有效率34.8%。毒副反应主要是粒细胞减少,发生率100%,恶心呕吐常见(52.5%),脱发(27.5%)及心脏毒性(2.5%)轻微。结论含THP联合方案治疗转移性乳腺癌及复治患者是一种有效的方案。Objective To study the clinical response and safety of regiman containing pirarubicin（THP） in treating metastatic breast cncer . Methods Forty patients with metastatic breast cancer were treated with combination chemotherapy of 5 - Fu 500mg/m^2 ,THP 50mg/m^2, CTX 500mg/m^2 once every 3 weeks. Results Overall response rate was 57.5% ,5 cases had complete remission （ CR）. The response rate in patients first treated or retreated, with skin -soft tissue lymphatic node metastases, and lung,liver metastases were 73.7% ,42.9% ,88.2% , and 34.8%, respectively. The main toxicity -side effect was leukopenia（ 100% ）. Nausea and vomiting were common （52.5%）. Cardiac toxicities（2.5% ） and alopecia（27.5% ）were rather mild. Conclusion Regimen containing THP is an effective and safe chemotherapy in metastatic and retreated breast cancer.

关 键 词：转移性乳腺癌 吡喃阿霉素 疗效 毒性 

分 类 号：R735.34[医药卫生—肿瘤]