放疗加化疗治疗直肠癌术后复发58例临床观察  

Study of late course three dimensional-conformal radiotherapy combined with chemotherapy for 29 cases with recurrent rectal cancer.

作　　者：高飞[1] 刘阳晨[1] 周绍兵[1] 叶宏勋[1] 赵莺[1] 尹小祥[1] 

机构地区：[1]泰兴市人民医院,江苏泰兴225400

出　　处：《现代肿瘤医学》2005年第6期777-779,共3页Journal of Modern Oncology

摘　　要：目的探讨后程适形放疗加化疗治疗术后复发直肠癌的疗效.方法 58例术后复发直肠癌随机分为后程适形放疗加化疗组(适形组)29例,普放加化疗组(对照组)29例.前程采用三野等中心照射40GY,后予适形推量至65～70GY,对照组后程用两斜野照射推量至DT55～60GY,两组均于放疗第一周予FP方案(5-Fu 500mg/m2 d1～5;DDP 30mg/m2 d1～3)化疗一周期,放疗结束后再化疗3～5周期.结果适形组和对照组3年局部控制率分别为65.5%、48.3%(P<0.05),适形组和对照组1、3年生存率分别为89.3%、58.6%和82.8%、41.3%(P<0.05),中位生存时间分别为30和21个月.毒副反应两组无统计学差异,患者均可耐受.结论后程适形放疗加化疗治疗术后复发直肠癌有较好疗效,毒副反应可耐受,值得推广使用.Objective To study the effect of recurrent rectal cancer teated by three dimensional - conformal radiotherapy（3D -CRT） combined with chemotherapy（CT）. Methods Total of 58 patients with recurrent rectal cancer were divided randomly into two groups ：29 cases received CT plus 3D -CRT（ 3D -CRT group） ;29 cases received CT plus conventional radiotherapy [ control group ]. A total tumor dose of 40 Gy by three - field from the same center for conventional radiotherapy in the first course; followed in the 3D - CRT group by 3D - CRT to DT65 - 70Gy,in the control group by two - field for conventional radiotherapy to DT55 -60Gy. Two goups were all treated one course by FP precept in the first week,and then 3 N 5courses were given after the end of radiotherapy. Results The 3 - year local regional control rates for 3D - CRT group and control group were 65.5% ,48.3% （P 〈 0.05） ; the 1 - and 2 - year survival rates for two groups were 89.3% ,58.6% and 82.8%, 41.3%（ P 〈 0.05 ） , middle survival time were 30 and 21 months. The side effects were similar in the two groups. Conclusion 3D - CRT plus CT may significantly improve the effect of the treatmentin in recurrent rectal cancer patients.

关 键 词：直肠肿瘤 适形放疗 化疗 

分 类 号：R735.37[医药卫生—肿瘤]