脑胶质瘤中PTEN、MMP2与MMP9表达的研究  

Expression of PTEN,MMP2 and MMP9 in gliomas.

作　　者：王虎[1] 浦佩玉[2] 王广秀[2] 董伦[2] 康春生[2] 李捷[2] 王春艳[2] 焦德让[1] 

机构地区：[1]天津市环湖医院,天津300060 [2]天津医科大学总医院神经外科

出　　处：《中国神经精神疾病杂志》2005年第6期419-421,i0014,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：本课题由国家自然科学基金(编号:39970338)资助

摘　　要：目的探讨PTEN、MMP2与MMP9在脑胶质瘤增殖、侵袭过程中的相互作用机制。方法应用SP 免疫组化法检测了50例不同级别脑胶质瘤中的3种蛋白表达情况。结果不同级别的脑胶质瘤中3种抗体的表达程度不同,Ⅱ级与Ⅲ、Ⅳ级肿瘤之间的表达差异具有统计学意义(P<0．01);PTEM与MMP2、MMP9在脑胶质瘤中的表达呈负相关(rMMP2=-0．27,rMMP9=-O．35,P<0．01)。结论 PTEN表达缺失可引起基质金属蛋白酶的过表达,从而使脑胶质瘤的侵袭性增强。Objective To study the interaction of PTEN, MMP2 and MMP9 in the proliferation and invasion of human gliomas. Methods The SP immunohistochemical method was used to measure the expression of those proteins in 50 gliomas with different grades. Results Expressions of those proteins were varied among different malignancy degree of gliomasl. Their differences of expression level among grade Ⅱ ,grade Ⅲ and Ⅳ were statistically significant （P 〈0. 01 ） ;PTEN expression was negatively correlated with the expression of MMP2 and MMP9 （rMMP2 = -0. 27, rMMP9 = -0. 35, P 〈 0. 01 ）. Conclusions Inactivation of PTEN will lead to the overexpression of MMP2 and MMP9, and enhances the prolieration and invation of gliomas.

关 键 词：胶质瘤PTEN MMP2 MMP9免疫组织化学 

分 类 号：R739.41[医药卫生—肿瘤]