重组人p53腺病毒注射液治疗肺癌并肺不张2例及文献复习  

The Treatment of Lung Cancer with Atelectasis by Recombinant Adenoviral Injection Containing Human p53 Gene:A Report of Two Cases and the Review of Literatures

作　　者：彭玉娜[1] 谭获[1] 徐军[2] 欧阳铭[2] 杨劲松[2] 黄健[3] 何伟[1] 

机构地区：[1]广州医学院第一附属医院肿瘤血液中心,广州市510230 [2]广州市呼吸疾病研究所 [3]广州医学院第一附属医院放射科

出　　处：《中国肿瘤临床》2005年第22期1305-1307,共3页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨重组人p53腺病毒注射液(rAd-p53)治疗肺癌并肺不张的疗效和安全性。方法:在纤维支气管镜下为2例肺癌并肺不张的患者直接向肿瘤组织中注射rAd-p53(今又生)治疗,观察疗效并进行文献复习。结果:1例患者局部注射rAd-p53后,用药一侧的肺部分复张,而未注射rAd-p53的对侧肺病灶进行性增大;另1例注射rAd-p53,14天后复查胸片发现病肺部分复张,37天后完全复张;2例患者第2次用药后均出现发热,口服消炎镇痛药处理后缓解。结论:rAd-p53局部注射治疗肺癌并肺不张有一定的疗效,主要不良反应为发热。To explore the efficiency and safety of the treatment on lung cancer with atelectasis by recombinant adenoviral injection containing human p53 gene （rAd-p53）. Methods： Through fibril bronchoscope, the adenoviral vector was injected into the tumour tissue of two patients with lung cancer and atelectasis, and the efficiency was observed and some of the related literatures were reviewed. Results： In one patient, the atelectasis was partly eliminated at the injection side after intratumor injection of rAd-p53, but the side where the injection was not done progressively enlarged. In the other one, 14 days after the injection, X-ray examination of the chest showed the lung reexpanded partly, and 37 days later, it recovered completely. The fever was detected in both of the two patients after the second injection, which could be relieved by oral administration of non-steroid anti-inflammatory drugs （NSAIDs）. Conclusions： Partial efficacy of lung cancer with atelectasis could attain by local injection of rAd-p53, with fever as its main adverse effect.

关 键 词：p53局部注射 肺癌 肺不张 

分 类 号：R734.2[医药卫生—肿瘤]