乙酰水杨酸－聚天冬酰胺棒状药物体外释放的研究  

STUDIES ON IN VITRO RELEASE OF ACETYL SALICYLIC ACID-α,β-POLY(3-HYDROXYPROPYL) ASPARMIDE CONJUGATE

作　　者：汤谷平[1] 陈启琪[1] 单达先[1] 孙华瑜[1] 胡秀荣[1] 

机构地区：[1]浙江医科大学药学系,杭州大学中心实验室

出　　处：《中国医药工业杂志》1996年第3期108-110,共3页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金

摘　　要：以乙酰水杨酸为模型药物，将药物以共价键键合于聚天冬酰胺高分子母体，制成棒伏。体外释放在Ｔｒｉｓ－ＨＣｌ（ＰＨ７．４）缓冲溶液介质中，温度为３７±０．１℃时，其释放初期的释药量为其膜剂的近１／３０，能较好地控制释药初期的“爆释”现象。The in vitro release of acetylsalicylic acid-α, β-poly(3-hydroxyPropyl) asparmide conjugate was studied. The drug was molded at 60℃ into 20mg rod. In Tris-HCl (PH=7.4) buffer (25ml, 37.0±0.1℃), its daily in vitro release was assayed by UV spectrophotometry at 295nm. The release Profile showed this drug rod released without any initial burst.

关 键 词：乙酰水杨酸 聚天冬酰胺 棒状药物 缓释 爆释 

分 类 号：R971.1[医药卫生—药品] R944.9[医药卫生—药学]