Facile Syntheses of New Pyrazolo[1,5-a]pyrimidines Derivatives via Reactions of Enaminones with Aminopyrazole  

作　　者：LI Ming WANG Shu-wen WEN Li-rong KE Zi-qin 

机构地区：[1]College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China [2]Department of Chemistry, Xinjiang Normal University, Urumuqi 830054, P. R. China

出　　处：《Chemical Research in Chinese Universities》2005年第6期663-667,共5页高等学校化学研究（英文版）

基　　金：SupportedbytheNationalNaturalScienceFoundationofChina(No.Y2003B01).

摘　　要：Ethyl 7-aryl-2-benzyhhiopyrazolo [ 1,5-a ] pyrimidine-3-carboxylates （3a-3f） were conveniently synthesized through the reactions of enaminones with 5-amino-3-benzyhhio4-ethoxycarbonyl-1 H-pyrazole in good yields and high regioselectivity. The structures of the new compounds were fully characterized by spectroscopic measurmehts, elemental analysis and X-ray diffraction analysis. A plausible reaction mechanism for the formation of the title compounds was also presented.Ethyl 7-aryl-2-benzyhhiopyrazolo [ 1,5-a ] pyrimidine-3-carboxylates （3a-3f） were conveniently synthesized through the reactions of enaminones with 5-amino-3-benzyhhio4-ethoxycarbonyl-1 H-pyrazole in good yields and high regioselectivity. The structures of the new compounds were fully characterized by spectroscopic measurmehts, elemental analysis and X-ray diffraction analysis. A plausible reaction mechanism for the formation of the title compounds was also presented.

关 键 词：Pyrazolo [ 1 5-a ] pyrimidine ENAMINONE Synthesis Mechanism Crystal structure 

分 类 号：O626.41[理学—有机化学]