不同浓度NK4对多种肿瘤细胞侵袭能力的影响  

Effect of NK4 in different concentrations on invasion of multiple tumor cells

作　　者：冯仟佳[1] 杨涛[1] 解军[1] 牛勃[1] 韩锐[2] 陈修贵[3] 梁冬明 

机构地区：[1]山西医科大学生物化学与分子生物学教研室,030001 [2]中国医学科学院中国协和医科大学药物研究所药理室 [3]杭州民生药业集团有限公司 [4]山西省一O九医院普外科

出　　处：《中国药物与临床》2005年第11期834-836,共3页Chinese Remedies & Clinics

摘　　要：目的研究不同浓度NK4因子对多种肿瘤细胞侵袭能力的影响。方法采用基底膜侵袭实验观察不同浓度NK4因子对人结肠癌、乳腺癌等多种肿瘤细胞侵袭能力的影响。结果在浓度为10μg/ml时,NK4因子对人结肠癌细胞、乳腺癌细胞、小鼠黑色素瘤细胞和人卵巢癌细胞侵袭重组基底膜的抑制率为56.4%,56.3%,56.1%和45.0%。结论NK4因子具有抑制人结肠癌、乳腺癌等多种肿瘤细胞侵袭的能力。Objective To study the effect of NK4 （a four-kringle fragment of hepatocyte growth-factor） at different concentrations on invasion of multiple tumor cells. Methods The invasive capacity of human colon cancer and breast cancer cells was evaluated by reconstituted basement membrane invasion assay. Results At a concentration of 10 μg/ml, NK4 factor suppressed human colon cancer cells, breast cancer cells, mouse melanoma cells and human oophoroma cells that invaded the reconstituted basement membrane by 56.4%, 56.3%, 56.1% and 45.0%. Conclusion NK4 factor can inhibit the invasion of multiple tumor cells, such as human colon cancer cells and breast cancer cells.

关 键 词：肿瘤侵润 肿瘤转移 NK4 

分 类 号：R73-3[医药卫生—肿瘤]