摄入过量钼对家兔不同组织中钼和铜含量的影响  

Effects of high levels molybdenum on contents of molybdenum and copper in different tissues in rabbits

作　　者：卜凤泉[1] 孙文伟[2] 刘景英[1] 姜熙罗[1] 刘忠英[1] 

机构地区：[1]吉林大学再生医学科学研究所分析生化室,吉林长春130021 [2]吉林大学中日联谊医院核医学科,吉林长春130031

出　　处：《吉林大学学报（医学版）》2005年第6期852-854,共3页Journal of Jilin University：Medicine Edition

基　　金：国家自然科学基金资助课题(30371757)

摘　　要：目的:观察在兔饲料中添加不同剂量钼(Mo)的家兔不同组织中钼和铜(Cu)的分布及其变化规律,研究钼对铜的生物学拮抗作用的机制。方法:家兔50只分为5组(对照组和添加不同剂量钼组),喂养4个月,测定兔不同组织中钼和铜含量。结果:兔血、肝、肺、脾、胰、心肌和骨骼肌中的钼和铜都随钼摄入量的增加而显著升高(P<0.01),钼和铜的增加曲线基本上呈对数曲线。肾中钼和铜含量在所有上述器官中其增加幅度最大,均与钼摄入量呈明显的线性关系(r=0.9995,r=0.9997)。成骨、软骨和毛发仅钼含量随钼摄入量的增加而显著增加(P<0.01),铜含量则基本无改变。结论:钼对铜的生物学拮抗作用,可能是在动物组织或血中形成的一种稳定的没有生物活性的Mo-Cu蛋白质络合物,堆积于组织不能被利用,因而造成铜相对缺乏状态。Objective To observe the distribution and change regularity of molybdenum （Mo） and copper （Cu） in blood and tissues in rabbits fed on supplement with different levels of Mo, and to study the biological antagonism of Mo on Cu. Methods Fifty rabbits were divided into five groups： control group and four experimental groups （treated with different doses of Mo）. The experimental time was four months. The contents of Mo and Cu in tissues of the rabbits were determined. Results Both Mo and Cu contents were increased in blood, liver, kidney, lung, spleen, pancreas, myocardium and muscle of rabbits with the increase of Mo intake in the diet （P〈0. 01）. The contents of Mo and Cu in kidney were increased remarkably, and closely related to Mo intake （r= 0. 9995, r= 0. 9997）. The contents of Mo in bone, cartilage and hair were also increased （P〈0. 01）, but not Cu when compared with control group. Conclusion The antagonism of Mo on Cu may be formed. Because Mo and Cu may he related to the stable Mo-Cu-protein complex without biological activity in blood or tissues. The complex heaping in blood or tissues can not be taken good advantage by the organism so that the animals show symptom of cooper-deficiency.

关 键 词：钼 铜 痕量元素 拮抗作用 动物 实验 

分 类 号：Q581[生物学—生物化学] R-332[医药卫生]