MMP-2、MMP-9和TIMP-1在胃癌组织中的表达及其与临床病理特点和预后的关系  

Relationships between expressions of MMP-2,MMP-9,TIMP-1 in gastric carcinoma and pathological characteristics and prognosis

作　　者：陈永胜[1] 潘留兰[1] 金珍婧[1] 杨力[1] 迟宝荣[2] 李静[3] 

机构地区：[1]吉林大学第二医院消化内科,吉林长春130041 [2]吉林大学第一医院消化内科,吉林长春130021 [3]内蒙古通辽市人民医院内镜室,内蒙古通辽028000

出　　处：《吉林大学学报（医学版）》2005年第6期927-930,共4页Journal of Jilin University：Medicine Edition

基　　金：吉林省发改委资助课题(2000-9)

摘　　要：目的:探讨基质金属蛋白酶(MMP-2、MMP-9)和金属蛋白酶组织抑制剂(TIMP-1)在胃癌中的表达及与临床病理特点和预后的关系。方法:应用免疫组织化学技术和形态定量分析方法。结果:MMP-2、MMP-9在胃癌基质中有表达,明显高于癌旁正常组织(P<0.01);TIMP-1分布于癌巢周边的基质中;MMP-2、MMP-9及TIMP-1在胃癌中的表达程度与患者的年龄、肿瘤大小、病理分级无关,而与患者的淋巴结转移情况相关(P<0.05)。结论:MMP-2、MMP-9和TIMP-1与胃癌的临床病理特点和转移预后密切相关,可作为判定胃癌生物学行为和预后的重要指标。Objective To study the relationships of expressions of MMP-2, MMP-9, TIMP-1 in gastric carcinoma and pathological characteristics in clinic metastasis and prognosis. Methods Immunohistochemistry and morphologic quantitative analysis were used. Results Expression levels of MMP-2 and MMP-9 in gastric carcinoma matrix were markedly higher than those of pericarcinoma normal tissues （P 〈 0.01 ）. TIMP-1 expressed in pericarcinoma matrix. There were no any relationships between the expression levels of MMP-2, MMP-9, TIMP-1 in gastric carcinoma and patients＇ age, tumor size, pathological grading, but there was obvious relationship between expression levels of MMP-2, MP-9, TIMP-1 and lymph node metastasis （P〈0. 05）. Conclusion There are close relationships between the expressions of MMP-2, MMP-9, TIMP-1 in gastric carcinoma and pathological characteristics in clinic metastasis and prognosis. They may be used as important indexes to judge the biological behavior and prognosis of gastric carcinoma.

关 键 词：胃肿瘤 明胶酶A 明胶酶B 金属蛋白酶组织抑制剂 

分 类 号：R735.2[医药卫生—肿瘤]