食管癌同期放化疗与血管内皮生长因子表达的关系  

Concurrent chemoradiotherapy and clinical significance of vascular endothelial growth factor in esophageal carcinoma

作　　者：陈德玉[1] 刘俊[1] 陈传生[1] 李君荣[2] 闻平[1] 

机构地区：[1]江苏大学附属医院肿瘤治疗中心,镇江212001 [2]江苏大学医学院,镇江212001

出　　处：《肿瘤》2005年第6期613-615,共3页Tumor

基　　金：江苏省卫生厅计划性项目(编号:H200355)

摘　　要：目的探讨食管癌同期放化疗与血管内皮生长因子表达水平的关系。方法将70例中、上段食管癌患者随机分为2组,研究组35例接受同期放化疗,对照组35例接受单纯放射治疗。运用酶联免疫吸附法(ELISA)检测2组患者治疗前、后血清中血管内皮生长因子(S-VEGF)水平,分析其与疗效的关系及临床意义。结果 2组患者治疗前后S-VEGF水平有显著性差异,研究组治疗前(548．65±253．94)pg／mL,治疗后(191．29±159．24)pg／mL(P＜0．001)；对照组治疗前(622．83±231．47)pg／mL,治疗后(412．26±263．86)pg／mL(P＜0．001)；治疗组与对照组治疗后的S-VEGF表达水平也有显著性差异(P＜0．001)。结论食管癌患者放射治疗后S-VEGF水平较治疗前明显降低；同期放化疗较单纯放疗后的S-VEGF水平显著降低；抗VEGF疗法在放疗中的应用值得研究。Objective To study the correlation between concurrent chemoradiotherapy and the level of vascular endothelial growth factor（VEGF） in patients with esophageal carcinoma. Methods Seventy patients with upper and middle esophageal cancer were randomized into two groups where 35 received concurrent chemoradiotherapy and 35 received radiotherapy alone. S（serum）VEGF was measured by enzyme-linked immunosorbent assay （ELISA） in both groups before treatment and 1 month after treatment. Then, the correlation between concurrent chemoradiotherapy and the level of S-VEGF in esophageal carcinoma was evaluated. Results S-VEGF levels were affected by both concurrent chemoradiotherapy and radiotherapy alone（548.65 ± 253.94 pg/ mL versus 191.29 ± 159.24 pg/mL in the study group, P 〈0. 001 and 622.83 ± 231.47 pg/mL versus 412.26 ± 263.86 pg/mL in the control group, P 〈0. 001 ）. A similar tendency was observed for the study group or control group（ P 〈0. 001 ）. Conclusion S-VEGF levels are significantly reduced in patients with esophageal cancer after radiotherapy. The patients who received concurrent chemoradiotherapy showed significantly less S-VEGF than those patients who received radiotherapy alone. The further investigation of anti VEGF therapy is needed.

关 键 词：食管肿瘤/放射疗法 食管肿瘤/药物疗法 血管内皮生长因子类 酶联免疫吸附测定 

分 类 号：R735.1[医药卫生—肿瘤]