几丁糖填充玻璃体腔对兔眼内组织结构影响的研究  

The effect of Chitosan on intraocular structure when filling in the vitreous cavity

作　　者：杨红[1] 王蓉[1] 张晓农[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院眼科,430030

出　　处：《中华眼科杂志》2005年第10期892-895,共4页Chinese Journal of Ophthalmology

基　　金：湖北省科技厅基金资助项目(2003AA301C16)

摘　　要：目的探讨几丁糖玻璃体腔填充对视网膜、睫状体、晶状体、角膜等眼内组织结构和眼压的影响。方法选择健康青紫蓝兔12只,右眼为实验组,左眼为对照组,行玻璃体切除术后,玻璃体腔内注入医用几丁糖(实验组)和透明质酸钠(对照组),手术前后定期行裂隙灯显微镜及检眼镜检查并测量眼压,术后行组织学和透射电镜检查。结果术后玻璃体腔内的填充物始终保持透明。视网膜平伏,未见视网膜脱离及增生。实验组与对照组在各时间点眼压比较,差异无统计学意义(P>0.05)。光镜及透射电镜检查结果发现,实验组及对照组镜下表现无明显差异,角膜、睫状体、晶状体及视网膜均无异常。结论几丁糖填充玻璃体腔内对眼组织结构无明显影响,也不引起眼压波动。Objective To study the effect of Chitosan on intraocular structure and pressure when filling in the vitreous body. Methods Chitosan were injected into vitreous cavity in twelve healthy vitrectomized pigmented rabbits in the right eyes （experiment group） and Hyalumnan in the left eyes （control group）. Slitlamp biomicroscopy and indirect ophthalmoscopy were performed and intraocular pressure were measured pre- and postoperatively in all eyes. Histopathological examination was done after the rabbits were sacrificed at the end of the study. Results All the results indicated that there were no significant differences between experiment group and control group. Conclusion There is no obvious effect on intraocular structure and intraocular pressure when the vitreous cavity is filled with Chitosan. （Chin J Ophthalmol, 2005,41：892- 895）

关 键 词：壳多糖 玻璃体切除术 注射 病灶内 兔 

分 类 号：R77[医药卫生—眼科]