多发性硬化合并癫临床特点分析  

Multiple sclerosis and epilepsy: a retrospective study

作　　者：刘彩燕[1] 徐雁[1] 崔丽英[1] 陈琳[1] 周祥琴[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院神经科,100730

出　　处：《中华神经科杂志》2005年第10期609-611,共3页Chinese Journal of Neurology

摘　　要：目的探讨多发性硬化(multiplesclerosis,MS)患者中合并癫的情况。方法回顾1981—2004年北京协和医院收治的临床确诊和实验室支持确诊的MS患者119例,分析其中合并癫患者的临床特点。结果MS患者发生癫的患病率为5.0%±0.1%,明显高于普通人群患病率的0.5%～1.0%。但是起病年龄、额叶皮质下以及侧脑室旁病灶、年复发率及扩展功能障碍状态量表(EDSS)评分与多发性硬化患者是否出现癫无统计学明显相关。颞叶皮质下病灶与多发性硬化患者出现癫存在统计学相关(P=0.035)。结论MS患者较普通人群易患癫,其中存在颞叶皮质下病灶的MS患者更易出现癫。Objective To explore the association of multiple sclerosis （MS） with epilepsy. Methods A retrospective review of 119 patients with definite MS was carried out in our hospital from 1981 to 2004 and the characters of cases were analyzed. Results The cumulative prevalence of epilepsy in MS patients was 5.0% ± 0. 1% , higher than that expected for the general population （0.5%-1.0% ）. The occurrence of epilepsy was not related to the age at onset, relapse rate per year, expanded disability status scale （EDSS）and the cortical-subcortical lesion of the frontal lobe as well as the paraventricular lesion. However, it was related to the cortical-subcortical lesion of the temporal lobe （ P = 0. 035 ）. Conclusion MS patients should be tend to have epilepsy, especially those who have the cortical-subcortical lesion of the temporal lobe.

关 键 词：多发性硬化 癫癎 回顾性研究 

分 类 号：R744.51[医药卫生—神经病学与精神病学]