β和γ射线放射性皮肤损伤动物模型的初步研究  

PRELIMINARY STUDY ON ANIMAL MODELS OF SKIN DAMAGE INDUCED BY β AND γ RADIATION

作　　者：周迎会[1] 吴士良[1] 王秀珍[1] 徐岚[1] 彭淼[1] 

机构地区：[1]苏州大学医学院生化及分子生物学教研室暨苏州大学生化工程研究所,215123

出　　处：《辐射防护》2005年第6期357-361,391,共6页Radiation Protection

基　　金：国防预研科研基金(Y6920026-04);国防基础科研计划(k0102061501)资助课题

摘　　要：采用直线加速器发射的β射线和60Co源γ射线分别照射动物局部组织,以建立放射性皮肤损伤动物模型。观察了局部组织生化代谢指标的改变及组织形态变化,论证两类放射性皮肤损伤动物模型的可行性并用其对放射性皮肤损伤产生的分子机制进行探讨。实验结果表明:(1)γ或β射线都能引起局部皮肤损伤,并在生化代谢指标方面有诸多相似之处;(2)初步建立的两类放射性皮肤损伤动物模型有一定的可行性。Animal local tissues were exposed to β rays emitted from the linear accelerator and γ-rays from ^60Co, respectively in order to develop the animal model of radiation-induced skin damage. The changes of biochemical metabolic index and tissue morphology were examined to verify the feasibility of two models and to study the molecular mechanism of radiation damage to skin. The experimental results showed： （ 1 ） Both γ rays and β rays could induce the local skin injury. Moreover the biochemical metabolic changes of the tissues are Similar to each other. （2）These two primary models of radiation induced skin damage are effective.

关 键 词：Β射线 Γ射线 皮肤损伤 动物模型 

分 类 号：R-332[医药卫生]