血清α－L－岩藻糖苷酶及糖类抗原CA－50对原发性肝细胞癌诊断的探讨  

Serum α-L-fucosidase and Carbohydrate antigen CA-50 for the Diagnosis of Hepatocellular Carcinoma

作　　者：庄宝珠[1] 奚淑芹 石田[1] 刘峥艳[1] 张恩杰 

机构地区：[1]中国医科大学第一临床学院消化内科,中国医科大学第一临床学院消化实验室,盘锦市辽河油田第一职工医院消化内科

出　　处：《中国医科大学学报》1996年第2期145-147,共3页Journal of China Medical University

摘　　要：对７８例原发性肝细胞癌（ＨＣＣ）、１５例其他消化道恶性肿瘤，１９例肝硬化、５例肝血管用及健康对照３０例，同时检测α－Ｌ－岩藻糖苷酶（ＡＦＵ）、糖类抗原ＣＡ－５０并与甲胎蛋白（ＡＦＰ）对照。结果：ＡＦＵ、ＣＡ－５０对ＨＣＣ诊断的阳性率分别为７６．２％和６９．２％高于ＡＦＰ（６２．８％）。２７例ＡＦＰ阴性的ＨＣＣ中，ＡＦＵ、ＣＡ－５０呈阳性者分别为１７和９例。三者联合检测诊断的特异性为８５．２％，敏感性达９１．１％。１６例术后检测结果，ＡＦＵ阴转率为８７．５％，ＣＡ－５０为８１．３％。ＡＦＵ和ＣＡ－５０做为诊断ＨＣＣ的标志物，对ＡＦＰ阴性者有互补诊断价值，联合检测诊断率更高。erum α-L-fucosidase(AFU) and carbohydrate antigen CA-50 were analysed in contrast to serumAFP in 78 patients with hepatocellular carcinoma (HCC),15 with malignant tumors,19 with hepaticcirrhosis,5 with hepatic angioma,and 30 healthy persons as a control.The positive rate of serum AFUand CA-50 was 76.2%and 69.2%respectively.These two values were higher than the value of serumAFP(62.8%).In 27 patients with HCC had mormal AFP value (AFP-negative HCC),the serum AFUin 17 patients and CA-50 in 9 were positive. The specificity of conbining this three markers was 85.2%,while the sensitivity was 91%. The results suggested that serum AFU and CA-50 were good markersfor the diagnosis of HCC, especially when they were used as complements for AFP-negative HCC.

关 键 词：原发性 肝肿瘤 岩藻糖苷酶 糖类抗原 诊断 

分 类 号：R735.704[医药卫生—肿瘤]