心脏粘液瘤DNA分析  

DNA Analysis in Cardiac Myxoma

作　　者：王新允[1] 谭郁彬[1] 赵凤喜[2] 李德芬[3] 章明放[1] 

机构地区：[1]天津医科大学病理教研室,300070 [2]天津医科大学总医院 [3]天津市胸科医院病理科

出　　处：《天津医药》1996年第3期140-142,共3页Tianjin Medical Journal

摘　　要：应用流式细胞仪对21例心脏粘液瘤DNA进行了分析,观察肿瘤细胞DNA倍体的变化和细胞动力学指标。结果显示:21例肿瘤中二倍体肿瘤有17例占80.95％。非整倍体肿瘤有4例占19.05％。非整倍体肿瘤的3例病人有栓塞现象,17例二倍体肿瘤的病人细胞增殖周期时相明显升高者有3例(≥23.6％),临床也有栓塞现象。这些结果表明非整倍体肿瘤或二倍体伴S+C_2M明显升高者,肿瘤细胞增殖活性增高,提示该肿瘤有潜在恶性的可能。The flow cytometric DNA analyses were performed in 21 paraffin - embedded cardie myxoma and correlated DNA ploidy status and proliferative fraction with clincial findings were investigated. Seventeen of 21 cases (80. 95%) were diploid and the remaining four cases (19. 05%) were aneuploid. Three patients with aneu-ploid experienced embolic phenomenon. Three of 17 cases with diploid myxomas demonstrated an elevated (more than 23.6%) proliferative cycle fraction and these patients experienced embolic phenomenon. This ploidy study suggested that cardiac myxoma with either aneuploid DNA content or elevated proliferative fraction may be associated with more aggressive biologic behavior.

关 键 词：肿瘤 粘液瘤 DNA 流式细胞仪 心脏肿瘤 

分 类 号：R732.102[医药卫生—肿瘤]