人类白细胞Ⅱ类抗原与颅内囊性动脉瘤发病关系的研究  

Study of the relationship between the HLA-DR,DQ antigen and intracranial aneurysm

作　　者：王江飞[1] 张东[1] 赵继宗[1] 贾保祥[2] 毕如玫[2] 尔秀江[2] 

机构地区：[1]首都医科大学附属北京天坛医院神经外科,100050 [2]首都医科大学附属北京友谊医院肾移植研究所

出　　处：《北京医学》2005年第12期705-707,共3页Beijing Medical Journal

基　　金：国家自然科学基金资助项目(编号:30200290)

摘　　要：目的探讨汉族人群中人类白细胞抗原(HLA)Ⅱ类抗原基因与颅内动脉瘤发病率的关系。方法利用PCR、琼脂糖胶电泳检测PCR产物等方法,比较49例颅内动脉瘤组与58例对照组中HLA!Ⅱ类抗原基因的DR及DQ位点的等位基因频率。结果汉族颅内动脉瘤患者的HLA!Ⅱ类抗原基因的DR及DQ等位基因频率与正常对照组无显著性差异(P>0.05)。结论汉族人的HLA!Ⅱ类抗原与颅内动脉瘤的发生可能无相关关系。Objective To investigate the relationship between the HLA-DR,DQ antigen and intracranial aneurysm in the Han nationality. Methods To detect the occurrence of HLA-DR and HLA-DQ antigens in the intracranial saccular aneurysm patients and the control group by PCR and agarose gel electrophoresis the HLA-DR and HLA-DQ antigens frequency and some haplotype frequency between these 2 groups were compared. Results No statistically significant correlation between HLA-DR, HLA-DQ antigens frequency and the pathogenesis and clinical characteristics of intracranial aneurysm were found. Conclusions There maybe no correlation between the HLA-DR,DQ antigen and intracranial aneurysm in the Han nationality.

关 键 词：人类白细胞抗原 聚合酶链式反应 颅内动脉瘤 

分 类 号：R739.4[医药卫生—肿瘤]