两种不同提取方式对枳子抗脂质过氧化反应的影响  

Effect of Two Different Extracts On Different Therapeutic Efficacy of Semen Hoveniae

作　　者：张洪[1] 刘秀玲[2] 王飞[2] 

机构地区：[1]武汉大学人民医院药学部,湖北武汉430060 [2]武汉大学药学院,湖北武汉430060

出　　处：《云南中医学院学报》2005年第4期21-23,共3页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：湖北省科技攻关项目(NO:202AA301C61)

摘　　要：目的:比较渗漉法提取物(Ⅰ)和使用索式提取器提取的提取物(Ⅱ)的抗脂质过氧化作用。方法:用腹腔注射四氯化碳致小鼠肝脏损伤模型,比较Ⅰ和Ⅱ对肝匀浆中超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量的影响。结果:与模型组相比,Ⅰ和Ⅱ均能显著提高动物模型中肝脏SOD活性和降低MDA含量,Ⅱ的作用更强。结论:使用索式提取器提取的提取物具有更强的抗脂质过氧化反应的作用。Objective： To compare different therapeutic efficacy of different extracts with the method of percolate （ Ⅰ） and with Soxhlet＇ s extracter （ Ⅱ ）. Method： The acute hepatic injury mode was prepared by EEl4 injected intraperitoneally, then, the therapeutic efficacy of Ⅰ and Ⅱ on the model were evaluated by the activity determination of superoxide dismutase （SOD） and the content of malondialdehyde （MDA） in liver. Result： The content of the MDA content in liver was significantly increased and the activity of SOD was laegely inhibited in the animals of model group, following the treatment with Ⅰ and Ⅱ , MDA content in liver was significantly reduced and SOD activity was obviously increased in the mice of treatment group. But MDA content reducing was displayed significant difference efficacy by Ⅰ and Ⅱ , larger effect was made by Ⅱ . Conclusion： The method with Soxhlet＇ s extracter possesses stronger prevention to the peroxidation action.

关 键 词：枳棋子 四氧化碳 提取方式 抗脂质过氧化 

分 类 号：R284.2[医药卫生—中药学]