Treatment of Zollinger-Ellison Syndrome  

作　　者：Paola Tomassetti Davide Campana Lydia Piscitelli Elena Mazzotta Emilio Brocchi Raffaele Pezzilli Roberto Corinaldesi 

机构地区：[1]Department of Internal Medicine and Gastroenterology University of Bologna, Italy

出　　处：《World Journal of Gastroenterology》2005年第35期5423-5432,共10页世界胃肠病学杂志（英文版）

摘　　要：In this article, we have reviewed the main therapeutic measures for the treatment of Zollinger-Ellison syndrome （ZES）. Review of the literature was based on computer searches （Pub-Med, Index Medicus） and personal experiences. We have evaluated all the measures now available for treating patients with sporadic gastrinomas or gastrinomas associated with Multiple Endocrine Neoplasia Type 1, （MEN 1） including medical therapy such as antisecretory drugs and somatostatin analogs （SST）, chemotherapy and chemoembolization, and surgical procedures. In ZES patients, the best therapeutic procedure is surgery which, if radical, can be curative. Medical treatment can be the best palliative therapy and should be used, when possible, in association with surgery, in a multimodal therapeutic approach.In this article, we have reviewed the main therapeutic measures for the treatment of Zollinger-Ellison syndrome (ZES). Review of the literature was based on computer searches (Pub-Ned, Index Medicus) and personal experiences. We have evaluated all the measures now available for treating patients with sporadic gastrinomas or gastrinomas associated with Multiple Endocrine Neoplasia Type 1, (MEN 1) including medical therapy such as antisecretory drugs and somatostatin analogs (SST),chemotherapy and chemoembolization, and surgical procedures. In ZES patients, the best therapeutic procedure is surgery which, if radical, can be curative.Medical treatment can be the best palliative therapy and should be used, when possible, in association with surgery,in a multimodal therapeutic approach.

关 键 词：GASTRINOMA Zollinger-Ellison Syndrome MEN 1 Proton pump inhibitors Somatostatin analogs CHEMOEMBOLIZATION 

分 类 号：R735.9[医药卫生—肿瘤]