慢性重型肝炎患者血清游离IGF-1检测及意义  

Detection of the serum free insulin-like growth factor 1 in patients with chronic severe hepatitis and its implication

作　　者：楼敏[1] 靳雪原[1] 鞠连才[1] 罗生强[1] 王晓峰[1] 

机构地区：[1]解放军第302医院感染内科,北京100039

出　　处：《解放军医学杂志》2005年第11期1027-1028,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：目的分析血清游离IGF1水平变化与慢性重型肝炎患者的病情发展和预后的关系。方法应用ELISA方法检测44例慢性重型肝炎、46例肝硬化和43例慢性肝炎患者血清游离IGF1水平。并与肝功能各项指标、凝血酶原活动度和胆碱酯酶进行对照。结果慢性重型肝炎、肝硬化和慢性肝炎患者血清游离IGF1水平分别为0.24±0.15、0.33±0.17和1.06±0.70ng/ml,慢性重型肝炎与肝硬化和慢性肝炎有显著性差异(P<0.01);慢性重型肝炎早、中期IGF1水平比较,差异无显著性(P>0.05);早期与晚期比较,差异有显著性(P<0.0);中期与晚期比较,差异亦有显著性(P<0.05)。死亡组32例患者的血清游离IGF1平均低于0.2ng/ml,而存活组12例患者平均高于0.35ng/ml。结论在慢性重型肝炎患者血清游离IGF1显著下降,并与重型肝炎严重程度有关,因此可作为判断慢性重型肝炎预后的一个重要指标。Objective To evaluate the relationship between the serum free IGF-1 level and the severity and prognosis in patients with chronic severe hepatitis. Methods Serum free IGF-1 was assessed by ELISA in 44 patients with chronic severe hepatitis, 43 chronic viral hepatitis, 46 liver cirrhosis. At the same time the liver function, prothrombin activity and cholinesterase were also determined. Results Serum free IGF-1 in patients with chronic severe hepatitis, liver cirrhosis and chronic viral hepatitis was 0.24±0. 15,0.33±0. 17 and 1.06 ~0. 70 （ng/ml）, respectively. IGF1 was significantly decreased in patients with chronic severe hepatitis and liver cirrhosis. IGF-1 level in patients with chronic severe hepatitis at early, middle and advanced stages was 0. 28±0. 07, 0. 27±0. 19 and 0. 16±0. 06 （ng/ml）, respectively. The reduction in the value showed a positive correlation with different stages of chronic severe hepatitis. Patients with chronic severe hepatitis having a serum free IGF-1 below 0. 2ng/ml had a higher mortality, and those with the value above 0.35ng/ml had a better chance to survive during the follow-up period. There was a significant positive correlation between serum free IGF-1 and prothrombin activity. Conclusion Serum free IGF-1 was decreased in the patients with chronic severe hepatitis. The clinical observation suggested that the serum free IGF-1 might be an important prognostic indicator in patients with chronic severs hepatitis.

关 键 词：胰岛素样生长因子1 肝炎 病毒性 人 预后 

分 类 号：R575.1[医药卫生—消化系统]