60Coγ射线离体照射诱发人精子和淋巴细胞染色体畸变的比较  

COMPARISONS OF CHROMOSOME ABERRATIONS INDUCED BY IN VITRO 60 Coγ-RAY IRRADIATIONS IN HUMAN SPERM AND LYMPHOCYTES

作　　者：刘金荣 傅宝华[1,2,3] 黄自明[1,2,3] 吕玉民[1,2,3] 任春仙 陈玉浩[1,2,3] 韩林[1,2,3] 赵风玲[1,2,3] 

机构地区：[1]山西省计划生育科学研究所 [2]河南省职业病防治研究所 [3]河南省肿瘤研究所

出　　处：《癌变．畸变．突变》1996年第4期207-211,共5页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：本文对６０Ｃｏγ射线离体照射诱发的人精子和淋巴细胞染色体畸变进行了分析。在对照、１．０１、１．８１和２．９９Ｇｙ剂量组，两类细胞的畸变细胞率和结构畸变率基本相同。结构畸变类型明显不同，精子染色体以断裂型畸变为主，是淋巴细胞断裂型畸变的４倍；淋巴细胞以互换型畸变为主，是精子互换型畸变的７倍。requencies and types of chromosome aberrations in human sperm and lymphocyte from one healthy man were compared after in vitro 60 Co γ-ray irradiation with 0,1.01,1.81 and 2.99Gy.The results indicated that the frequencies of chromosomal aberration and structural aberration were similar in two cell types,respectively.However,the types of structural chromosome aberrations were distinctly different.The incidence of breakage-type aberrations in sperm was about 4 times higher than that in lymphocyte;The incidence of exchange-type in lymphocyte was about 7 times higher than that in sperm.The possible cause that types of structural aberrations were distinctly different in the two cell types was discussed.The feasibility of using lymphocytes as surrogates for germ cells in genetic risk estimation was discussed.

关 键 词：γ射线离体照射 精子 淋巴细胞 染色体畸变 

分 类 号：R818.03[医药卫生—放射医学]