肠上皮细胞紧密连接的结构及功能研究进展  

The study of the molecular structure and function of intestinal epithelial tight junction proteins

作　　者：张中伟[1] 秦环龙[1] 

机构地区：[1]上海交通大学附属第六人民医院外科,上海200233

出　　处：《肠外与肠内营养》2005年第6期367-369,381,共4页Parenteral & Enteral Nutrition

基　　金：国家自然科学基金资助项目(批准号:30271286和30471687)

摘　　要：紧密连接(TJ)是维持肠黏膜上皮细胞间机械屏障的重要结构基础。除C laud in蛋白、occ lud in蛋白、ZO-1等重要组成蛋白外,目前已有40多种TJ相关蛋白分子陆续被发现。研究表明,TJ结构不但具有调节细胞间物质转运和维持上皮极性的功能,而且其相关蛋白分子还参与细胞增殖分化、肿瘤抑制、基因转录等过程的信息传递和调控。本文作者就TJ蛋白分子的最新发现及其功能作一综述,旨在了解TJ在肠道屏障功能中的作用。Tight junctions are the primary structure of intestional epithelial cells, which maintains the integrity of the epithelial cell layers. Besides claudins, occludins and ZO-1, more than 40 different proteins have been discovered. The tight junctions （TJs） serve not only as the barrier to the passage of ions and molecules through the paracellula pathway and maintenance of epithelial cell polarity, but also to integrate such diverse processes as cell growth and differentiation, tumor suppression, gene transcription. This review is about the recent discovery of TJ proteins and their functions, which will lead to the complement about intestinal barrier function.

关 键 词：肠上皮细胞 肠道屏障 紧密连接 

分 类 号：R574[医药卫生—消化系统]