硫酸伪麻黄碱的研制  

Synthesis of pseudoephedrine sulfate

作　　者：李莉[1] 陈坚[1] 李新霞[1] 

机构地区：[1]新疆医科大学药学院药化有机教研室,新疆乌鲁木齐830054

出　　处：《中国药学杂志》2005年第23期1829-1831,共3页Chinese Pharmaceutical Journal

摘　　要：目的研究易于产业化的硫酸伪麻黄碱的制备方法。方法 以工厂中间产品伪麻黄碱粗品为原料,经精制得伪麻黄 碱,然后与硫酸合成硫酸伪麻黄碱;并考察了影响伪麻黄碱精制的因素,以及不同结晶方法和硫酸浓度对硫酸伪麻黄碱产品 质量的影响。结果确定了两种结晶方法及制备条件。结论所制备硫酸伪麻黄碱各项指标符合美国药典23版标准。OBJECTIVE To investigate the synthesis of pseudoephedrine sulfate.METHODS Pseudoephedrine sulfate was obtained on basis of developing pseudoephedrine. And its preparation condition was estimated. RESULTS Two ways to obtain crystals were investigated to identify the pseudoephedrine sulfate＇s strong solubility in water, which made crystallizing difficult. CONCLUSION Pseudoephedrine sulfate obtained according to the demands of USP ⅩⅩⅢ.

关 键 词：硫酸伪麻黄碱 生产 

分 类 号：R914[医药卫生—药物化学]