胃腺癌组织中血管内皮生长因子的表达  

Expression of VEGF in gastric adenocarcinoma tissue

作　　者：王怀生[1] 张钦宪[2] 陈奎生[1] 高冬玲[1] 

机构地区：[1]河南省肿瘤病理重点实验室郑州大学第一附属医院病理科 [2]郑州大学基础医学院组织学与胚胎学教研室,郑州450052

出　　处：《郑州大学学报（医学版）》2005年第6期1109-1112,共4页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨胃腺癌组织中血管内皮生长因子(VEGF)的表达。方法:应用免疫组织化学SP方法,对56例胃腺癌组织,其中男32例,女24例,年龄31～75(56.38±12.1)岁;组织学分级为Ⅰ级15例,Ⅱ级29例,Ⅲ级12例;TNM分期Ⅰ期4例,Ⅱ期16例,Ⅲ期24例,Ⅳ期12例;高分化腺癌11例,中等分化腺癌25例,低分化腺癌20例;浸润至黏膜下层以内15例,肌层27例,浆膜层14例;有淋巴结转移者34例,无淋巴结转移者22例;40例癌旁不典型增生组织和56例正常胃组织中VEGF的表达情况进行检测,并分析其与临床病理特征的关系。结果:胃腺癌组织、癌旁不典型增生组织及正常胃黏膜组织中VEGF的阳性表达率分别为69.64%、45.00%和23.21%,3组间两两比较,差异均有统计学意义(P<0.01);VEGF与胃腺癌的浸润深度、淋巴结转移、组织学分级、临床病理分期有关(P<0.05或0.01),与患者年龄、性别及胃腺癌的分化程度无关(P>0.05)。结论:VEGF与胃腺癌的发生发展及浸润转移有关。Aim ： To investigate the expression of vascular endothelial growth factor（VEGF） in gastric adenocarcinoma tissue. Methods： The VEGF expression in 56 cases of gastric adenocarcinoma tissue,40 cases of atypical hyperplasia tissue adjacent to gastric adenocarcinoma and 56 cases of normal gastric tissue was detected using immunohistochemistry. Results： The positive rates of VEGF in gastric adenocarcinoma tissue, atypical hyperplasia tissue, and normal gastric tissue were 69.64% ,45.00%, and 23.21% ,respectively, and the difference between any two groups was significant （X^2 = 54.47, P 〈 0. 01 ） ; VEGF was correlated with the degree of the invasion depth, histological classification, lymphatic metastasis, and pathology period of gastric adenocarcinoma（ P 〈 0.05 or 0.01 ） ; it had no correlation with age, sex or differentiation degree（ P 〉 0.05）. Conclusion ： VEGF is correlated with the carcinogenesis, development,invasion and metastasis of gastric adenocarcinoma.

关 键 词：血管内皮生长因子 胃肿瘤 浸润 转移 

分 类 号：R735.2[医药卫生—肿瘤]