左旋卡尼汀(雷卡)对急性病毒性心肌炎的治疗作用  

Therapeutic effect of indigenous L-carnitine on acute viral myocarditis

作　　者：张治宇[1] 殷仁富[1] 陈金明[1] 钱伟[1] 时慧绮[1] 顾书华 

机构地区：[1]第二军医大学长征医院心内科,上海200003 [2]常州三维工业技术研究所,江苏常州213000

出　　处：《心脏杂志》2005年第6期564-566,共3页Chinese Heart Journal

摘　　要：目的:观察左旋卡尼汀(L-carn itine,L-CN)治疗急性病毒性心肌炎的临床疗效。方法:选择急性病毒性心肌炎患者80例,随机分为两组:对照组(40例)给予复方丹参注射液、黄芪注射液、维生素C等常规药物治疗;L-CN组(40例)在常规治疗的基础上加用L-CN治疗。结果:与对照组相比,L-CN组临床治愈率为52.5%(vs30.0%),有统计学差异(P<0.05)。L-CN重症亚组与对照重症亚组比较,临床治愈率(52.9%vs15.8%)、心律失常治愈率(29.4%vs10.5%)和治疗后3月LVEF(69.2%±0.9%vs65.2%±1.5%),均差异显著(P<0.05)。结论:L-CN能进一步提高治疗急性病毒性心肌炎的临床有效率。AIM： To observe the therapeutic effect of L-carnitine （L-CN） on acute METHODS： Eighty patients with viral myocarditis were randomly divided into L-CN viral myocarditis, group and the control group. The control group received routine treatment, and L-CN group received L-CN （3.0 g/d, VD x 14 d）in addition to the routine treatment. RESULTS： In L-CN group, 52.5% recovered compared with 30.0% in the control group （P 〈 0.05 ）. Among more serious patients, 3 months after the treatment, 52.9% recovered, 29.4% showed no arrhythmia and 69.2% showed improved LVEF, with significant differences from the control （ P 〈 0.05 ）. CONCLUSION ： L-carnitine combined with routine therapy might be a safe an effective way in the treatment of viral myocarditis.

关 键 词：肉碱 心肌炎 心功能 心律失常 

分 类 号：R542.21[医药卫生—心血管疾病]