止泻口服补液盐治疗小儿腹泻的临床研究  

Clinical study of antidiarrhea and rehydration salts in the treatment of infantile diarrhea

作　　者：徐海波[1] 路苓[1] 宫德鸿[1] 

机构地区：[1]枣庄市立医院儿科,山东枣庄277102

出　　处：《食品与药品》2005年第12A期45-46,共2页Food and Drug

基　　金：枣庄市科学基金资助项目

摘　　要：目的研制通过口服既能止泻又能补液、补电解质的配方。方法 2003年1月至2004年10月治疗小儿腹泻1 086 例,随机分为A组(止泻口服补液盐)500例、B组(口服补液盐)312例、C组(米粉口服补液盐)274例。按世界卫生组织规定的口服补液标准方案治疗。于24h、48 h、72 h观察脱水、腹泻纠正的例数。结果 A组与B组、A组与C组24 h、48 h比较脱水纠正例数无显著差异(P>0．05),腹泻纠正的例数A组效果较好,差异有统计学意义(P<0．05)。结论止泻口服补液盐的止泻作用明显优于口服补液盐和米粉口服补液盐,补液、补电解质作用差异无统计学意义。Objective To study a solution which can both stop diarrhea and supply the lost water and electrolytes.Methods 1086 infantile diarrhea cases selected from out-patient clinic and ward since Jan 2003 to Oct 2004 in our hospital were randomly divided into three groups： group A （500 cases receiving antidiarrhea and rehydration salts）, group B （312 cases receiving oral rehydration salts） and group C （274 cases receiving rice flour rehydration salts）.The patients were prescribed according to WHO oral rehydration standard. The effects of correcting diarrhea and dehydration were observed after 24 hours, 48 hours and 72 hours. Results By comparing group A with group B or group C after receiving treatment for 24 hours and 48 hours, it was found that there were no remarkable differences in correcting dehydration among them （P〉0.05）, but group A was significantly better in correcting diarrhea （P〈0.05）. Conclusion The effect of antidiarrhea and rehydration salts is superior in stopping diarrhea to oral rehydration salts or rice flour rehydration salts, but the effects of the three preparations in rehydration and supplying the lost electrolytes have no notable differences.

关 键 词：止泻药 口服补液盐 腹泻 儿童 

分 类 号：R574.62[医药卫生—消化系统]