电刺激致猪心室颤动及心肺复苏过程中β肾上腺素能受体变化规律的研究  

Study βAR Density Change Regularity of Pigs inCardiac Arrest and CPR

作　　者：王彤[1] 黄子通[1] 吴海东[1] 符岳[1] 林小鸿[1] 常瑞明[1] 杨柳青[1] 杨鹰[1] 

机构地区：[1]中山大学附属第二医院急诊科,510120

出　　处：《岭南急诊医学杂志》2005年第4期241-243,共3页Lingnan Journal of Emergency Medicine

摘　　要：目的:研究猪心室颤动及心肺复苏(CPR)过程中外周血淋巴细胞β肾上腺素能受体(βAR)密度的变化规律.方法:对10头猪在CPR前后取外周血,用3H-DHA放射性配基法测定其外周血淋巴细胞βAR密度.结果:猪外周血淋巴细胞βAR密度在CPR后升高,2 h达峰值,4 h后下降至正常偏低的水平.结论:猪心室颤动及CPR过程中外周血淋巴细胞βAR密度的变化规律,可能用于指导进一步的实验性及临床上的药物研究.Objective：To study change regularity of beta-adrenoceptor （βAR） density by measuring circulating lymphocyteβAR density of pigs during the period of cardiac arrest and cardiopulmonary resuscitation（CPR）. Methods： βAR density was measured in circulating lymphocyte of 10 pigs in cardiac arrest and CPR with ^3H-dihydroalpneold as ligand. ResuLts：Circulating lymphocyteβAR density gradually increased in early CPR. Conclusion：Change regularity of βAR density of circulating lymphocyte in cardiac arrest and CPR can make it possible to study drug-induced βAR changes.

关 键 词：心跳骤停 心肺复苏 Β肾上腺素能受体 淋巴细胞 

分 类 号：R541.7[医药卫生—心血管疾病]