肝气逆肝气郁两证患者发病前后血清甲状腺素含量测定结果分析  

ANALYSIS ON SERUM THYROXIN BEFORE AND AFTER GETTING SICK IN PATIENTS WITH LIVER - QI IN- VASION SYNDROM AND LIVER - QI DEPRESSION SYNDROM

作　　者：李秀芹 魏霞[2] 乔明琦[2] 张惠云[2] 

机构地区：[1]山东省委机关医院,山东济南250001 [2]山东中医药大学,山东济南250014

出　　处：《山东中医药大学学报》2005年第5期359-361,共3页Journal of Shandong University of Traditional Chinese Medicine

基　　金：国家中医药管理局资助课题(编号:200-J-P-02)

摘　　要：目的:进一步揭示机体生物学因素在肝气逆、肝气郁两证发病机制中的作用。方法:对肝气逆、肝气郁两证患者发病前后血清甲状腺素水平进行放免检测并与正常组进行对照研究。结果:两证组在无症状增殖期与分泌期T3水平正常,与正常对照组相比无明显差异。经前期证候呈现时,肝气逆证组T3含量显著降低,与前两期相比差异显著,月经来潮后症状消失,T3亦趋正常。肝气郁证组经前期T3水平未有明显改变,但月经期T3水平却显著降低;两证组发病前后血清T4含量均显著高于同期正常对照组,月经前后两证组自身对照无明显改变;两证组经前期血中促甲状腺素(TSH)含量显著高于其他三个时期,亦显著高于同时期的正常对照组。结论:研究认为血清总T3含量变化是肝气逆、肝气郁两证发病机制之一,T4水平异常升高则是肝气逆、肝气郁两证发病的内在条件,肝气逆证主要与甲状腺素(T3)分泌减低有关,肝气郁证则尚与垂体前叶促甲状腺素和甲状腺素反馈性调节失灵有关。Objective： to explore the function of the biological factor in syndrom pathogenesis of liver-q/invasion and liver-qi depression. Methods： radiation immunity method was adopted to examine serum thyroxin in two syndromes patients. Results： the levels of T3 in two syndromes patients are normal in proliferation and secretion periods, have no difference in contrast with normal group. But contents of T3 in liver- qi group decreases evidently in contrast with two periods before menses, and the symptom disappears after menstrual flow, and the contents of T3 go to normal level. Level of T3 in liver- qi depression group has no difference in premenstrual period, but has distinct decrease in menses period, the two syndromes patients contents of T3 in serum before and after getting sick are higher than normal group in the same period and have no difference in contrast with themselves; the two syndromes patients contents of TSH in serum are higher than the other three periods and normal group in the same period distinctly. Conclusion： the contents change of T3 is one of the pathogenesis of liver-qi invasion syndrome and liver-q/ depression syndrome. The abnormal elevation of T4 level is two syndromes＇ nosogenesis in the body. Liver-qi invasion has very close relation to the decrease of the level of T3. However liver-qi depression has relation to the level of TSH and disorder of thyroxin feedback adjustment.

关 键 词：经前期紧张综合征 肝气逆 肝气郁 甲状腺素 

分 类 号：R228[医药卫生—中医基础理论]