肿瘤坏死因子在年龄相关性黄斑变性脉络膜新生血管膜中的表达  

Identification of tumor necrosis factor-α in choroidal neovascular membranes

作　　者：姜岩 何世坤[2] 

机构地区：[1]辽宁省本溪市中心医院眼病防治中心,117000 [2]美国南加州大学Keck医学院Doheny眼科研究所,90033

出　　处：《眼科研究》2005年第6期568-571,共4页Chinese Ophthalmic Research

摘　　要：目的探讨肿瘤坏死因子(TNF-α)及其他相关炎性因子在年龄相关性黄斑变性(ARMD)脉络膜新生血管膜(CNVM)中的表达。方法采用免疫组织化学染色法检测手术切除的ARMD患者的CNVM中TNF-α的表达。结果所有检测的10例CNVM TNF-α染色呈阳性。阳性染色细胞以视网膜色素上皮(RPE)细胞及巨噬细胞为主,且多见于新生血管增殖活跃的区域。其他炎性反应因子例如ICAM-1及HLA-DR也有所表达。结论TNF-α很可能是脉络膜新生血管形成的重要病理因素之一。Objective To investigate the expression of tumor necrosis factor （TNF-α） in surgical excised choroidal neovascular membranes. Methods lmmunohistochemistry was used to identify the expression of inflammatory factor-TNF-α in choroidal neovascularization membrane （CNVM） in 10 patients with age-related macular degeneration （ ARMD）. Results All of CNV membranes stained in the experiment were positive for TNF-α. Double staining demonstrated retinal pigment epithelial cells,macrophages and endothelial cells were over lapped with TNF-α in CNVMs. Most of TNF-α positive cells were located in cellular rich areas of active neovascularization. Conclusion TNF-α may play an important role in the pathogenesis of choroidal neovascularization.

关 键 词：肿瘤坏死因子-Α RPE细胞 脉络膜新生血管膜 

分 类 号：R774.5[医药卫生—眼科]