Histamine ameliorates spatial memory deficits induced by MK-801 infusion into ventral hippocampus as evaluated by radial maze task in rats  

作　　者：Li-sha XU Li-xia YANG Wei-wei HU Xiao YU Li MA Lu-ying LIU Er-qing WEI Zhong CHEN 

机构地区：[1]Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031, China

出　　处：《Acta Pharmacologica Sinica》2005年第12期1448-1453,共6页中国药理学报（英文版）

基　　金：Project supported by the National Natural Science Foundation of China(No 30000019,30371638,30472013);the Zhejiang Provincial Natural Science Foundation of China(No R303779).

摘　　要：Aim：To investigate the role of histamine in memory deficits induced by MK-801 infusion into the ventral hippocampus in rats. Methods： An 8-arm radial maze （4 arms baited） was used to assess spatial memory. Results： Bilateral ventral intrahippocampal （ih） infusion of MK-801 （0.3μg/site）, an N-methyl-D-aspartate （NMDA） antagonist, impaired the retrieval process in both working memory and reference memory. Intrahippocampal injection of histamine （25 or 50 ng/site） or intraperitoneal （ip） injection of histidine （25, 50 or 100 mg/kg） markedly ameliorated the spatial memory deficits induced by MK-801. Both the histamine H1 antagonist pyrilamine （0.5 or 1.0 μg/site, ih） and the H2 antagonist cimetidine （2.5 μg/site, ih） abolished the ameliorating effect of histidine （100 mg/kg, ip） on reference memory deficits, but not that on working memory deficits induced by MK-801. Conclusion： The results indicate that histamine in the ventral hippocampus can ameliorate MK-801-induced spatial memory deficits, and that histamine＇s effect on reference memory is mediated by postsynaptic histamine H1 and H2 receptors.Aim：To investigate the role of histamine in memory deficits induced by MK-801 infusion into the ventral hippocampus in rats. Methods： An 8-arm radial maze （4 arms baited） was used to assess spatial memory. Results： Bilateral ventral intrahippocampal （ih） infusion of MK-801 （0.3μg/site）, an N-methyl-D-aspartate （NMDA） antagonist, impaired the retrieval process in both working memory and reference memory. Intrahippocampal injection of histamine （25 or 50 ng/site） or intraperitoneal （ip） injection of histidine （25, 50 or 100 mg/kg） markedly ameliorated the spatial memory deficits induced by MK-801. Both the histamine H1 antagonist pyrilamine （0.5 or 1.0 μg/site, ih） and the H2 antagonist cimetidine （2.5 μg/site, ih） abolished the ameliorating effect of histidine （100 mg/kg, ip） on reference memory deficits, but not that on working memory deficits induced by MK-801. Conclusion： The results indicate that histamine in the ventral hippocampus can ameliorate MK-801-induced spatial memory deficits, and that histamine＇s effect on reference memory is mediated by postsynaptic histamine H1 and H2 receptors.

关 键 词：HISTAMINE maze： learning MK-801 working memory： reference memory ventral hippocampus histamine H1 receptor 

分 类 号：R749.1[医药卫生—神经病学与精神病学]