激活素A异常表达与大肠癌血管生成的关系  

Overexpression of Activin A Correlates with Angiogenesis in Colorectal Carcinoma

作　　者：徐梅华[1] 蔡克银[1] 黄尚珍[1] 张小菊[1] 

机构地区：[1]广州军区武汉总医院老年病二科,武汉430071

出　　处：《临床消化病杂志》2005年第6期276-278,共3页Chinese Journal of Clinical Gastroenterology

摘　　要：目的探讨激活素A(ACTA)的表达与大肠癌血管生成的关系。方法应用免疫组化法检测56例大肠癌组织及癌旁组织中ACTA及血管内皮生长因子(VEGF)的表达及微血管密度(MVD)。结果56例大肠癌组织中ACTA阳性表达率为45.2%,明显高于癌旁组织的12.3%(P<0.01)。ACTA蛋白的表达在大肠癌淋巴结转移组高于无转移组(60.9%vs41.2%,P<0.01),DukesD期高于DukesA、B期,差异有显著性(分别为66.7%vs33.3%,66.7%vs44.4%,P均<0.01)。ACTA表达阳性组MVD值为84.0±10.8,明显高于阴性组的52.0±9.7(P<0.01)。大肠癌组织中ACTA的表达与VEGF的表达呈显著性正相关(r=0.712,P<0.01)。VEGF蛋白表达与MVD亦呈正相关(r=0.747,P<0.01)。结论ACTA与大肠癌的血管生成有关,可作为判断大肠癌侵袭和转移潜能的生物学指标。Objective To investigate the relationship between expression of activin A （ACT A）and angiogenesis in colorectal cancer （CRC）. Methods Expression of ACT A protein and vascular endotheliul growth factorl （VEGF） protein as well as microvessel density （MVD） were dected by immunohischemical methods in 56 CRC as well as adjacent normal colorectal tissue samples. Results Expression of ACT A mRNA was detected in a signiificantly greater proportion of colorectal carcinoma samples than that adjacent normal coorectal tissues （45.2% vs 12.3%, P 〈0.01 ）. The positive rate of ACT A protein expression in CRC with lymph modes metastasis was significently higher than non-metastic lesions （60.9% vs 41.2%P 〈0. 01 ）. The positive rate of ACT A protein expression in tumors with Dukes＇ stage D was significently higher than that Dukes＇ stage A and B （66.7% vs 33.3% ,66.7% vs 44. 4% respectivly ,P 〈0.01 for both）. The MVD value in ACT A positive group was 84.0 ± 10.8,which was much higher than that in negative group（ 52.0± 9.7）. There was a positive correlation between the positive rate of ACT A protein expression and that of VEGF in CRC tissues （r = 0. 712, P 〈 0. 01 ）. The expression of ACT A also positively correlated with MVD（ r = 0. 747, P 〈 0.01 ）. Conclusion ACT A was associated with angiogenesis and might be regarded as a biomarker for the potentialities of invasion and metastasis of colorectal carcinoma.

关 键 词：激活素A血管生成 微血管密度 血管内皮生长因子 

分 类 号：R735.34[医药卫生—肿瘤]