Sodium Amalgam, a Useful Reducing Reagent for Formation of Amines from Azides Bearing a Variety of Functional Groups  

作　　者：陆标 谢小安 朱继东 马大为 

机构地区：[1]Department of Chemistry, Fudan University, Shanghai 200433, China [2]State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2005年第12期1637-1640,共4页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （No. 20132030） and the Science and Technology Commission of Shanghai Municipality （No.02JC14032）.

摘　　要：Reduction of azides to amines without touching benzyl, t-butyldimethylsilyl, t-butyldiphenylsilyl, trityl and tetrahydropyranyl ether protecting groups, C-C double and triple bond, as well as aromatic bromide and nitrile functional groups, was achieved using sodium amalgam as a reducing reagent in methanol at temperature from -40℃ to room temperature. However, ester group was reduced under this condition.Reduction of azides to amines without touching benzyl, t-butyldimethylsilyl, t-butyldiphenylsilyl, trityl and tetrahydropyranyl ether protecting groups, C-C double and triple bond, as well as aromatic bromide and nitrile functional groups, was achieved using sodium amalgam as a reducing reagent in methanol at temperature from -40℃ to room temperature. However, ester group was reduced under this condition.

关 键 词：sodium amalgam AZIDES reduction 

分 类 号：O614.112[理学—无机化学]