L-酪氨酸合成手性噁唑烷酮的研究  

Studies on synthesis of chiral oxazolidin one from L-tyrosine

作　　者：卢翠芬[1] 杨桂春[1] 陈祖兴[1] 

机构地区：[1]湖北大学化学与材料科学学院,湖北武汉430062

出　　处：《湖北大学学报（自然科学版）》2005年第4期366-368,共3页Journal of Hubei University：Natural Science

基　　金：国家自然科学基金(No:20372019)资助

摘　　要：以L-酪氨酸为原料合成了化合物1和化合物2，化合物2与NaBH4在THF下回流过夜，还原完毕后加少量水继续回流7～8h就可直接得到关环产物3，总产率为40．8％．在反应体系中，水的存在促进了关环产物的生成，使还原和成环在一个单一的过程中就可完成．Compounds 1 and 2 have been synthesized from L - tyrosine. Refluxing a THF solution of compound 2 with NaBH4, after the reduction step was completed,then adding several drops of water and refluxing 7 - 8 h formed oxazolidin - one 3 directly, and total yield of the tree steps was 40.8 %. In our reactions, existing of a little water promoted the cyelization , and made the reduction and eyclization steps be accomplished in a single operation.

关 键 词：L-酪氨酸 还原 关环 手性嗯唑烷酮 

分 类 号：O626.24[理学—有机化学]